PXD014162
PXD014162 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The purine biosynthesis regulator PurR moonlights as a virulence regulator in Staphylococcus aureus |
| Description | To adapt to different environments, S. aureus relies on a complex and finely tuned regulatory network. While some of these networks have been well elucidated, the functions of more than 50% of the transcriptional regulators in S. aureus remain unexplored. Here, we assess the contribution of the LacI family of metabolic regulators to staphylococcal virulence. Through the use of transcriptomics and proteomics, we revealed that a number of virulence factors are differentially regulated in the absence of purR. Our findings highlight that S. aureus repurposes a metabolic regulator to directly control the expression of virulence factors, and by doing so, tempers its pathogenesis. |
| HostingRepository | MassIVE |
| AnnounceDate | 2019-06-07 |
| AnnouncementXML | Submission_2019-06-07_12:31:09.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Avantika Dhabaria |
| SpeciesList | scientific name: Staphylococcus aureus; NCBI TaxID: 1280; |
| ModificationList | iodoacetamide - site C; L-methionine sulfoxide; deglycosylated asparagine; deamidated L-glutamine |
| Instrument | instrument model: Q Exactive HF-X (Thermo Fisher Scientific) |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2019-06-06 08:12:33 | ID requested | |
| ⏵ 1 | 2019-06-07 12:31:10 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: PurR, Staphylococcus aureus, Label free, Virulence factors |
Contact List
| Beatrix Ueberheide | |
|---|---|
| contact affiliation | NYU School of Medicine |
| contact email | beatrix.ueberheide@nyulangone.org |
| lab head | |
| Avantika Dhabaria | |
| contact affiliation | NYUMC |
| contact email | avantika.dhabaria@gmail.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000083904 |
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