PXD014132

PXD014132 is an original dataset announced via ProteomeXchange.

Title	Interactions between host and gut microbiota following dietary interventions
Description	Increasing the consumption of dietary fibre has been proposed to alleviate the progression of non-communicable diseases such as obesity, type 2 diabetes and cardiovascular disease, yet the effect of dietary fibre on host physiology remains unclear. In this study, we performed a multiple diet feeding study in C57BL/6J mice to compare high fat and high fat modified with dietary fibre diets on host physiology and gut homeostasis by combining proteomic, metagenomic, metabolomic and glycomic techniques with correlation network analysis. We observed significant changes in physiology, liver proteome, gut microbiota and SCFA production in response to high fat diet. Dietary fibre modification did not reverse these changes but was associated with specific changes in the gut microbiota, liver proteome, SCFA production and colonic mucin glycosylation. Furthermore, correlation network analysis identified gut bacterial-glycan associations.
HostingRepository	PRIDE
AnnounceDate	2021-09-08
AnnouncementXML	Submission_2021-09-08_09:53:50.299.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Daniel BUCIO NOBLE
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2019-06-05 01:54:47	ID requested
⏵ 1	2021-09-08 09:53:51	announced

Gamage HKAH, Chong RWW, Bucio-Noble D, Kautto L, Hardikar AA, Ball MS, Molloy MP, Packer NH, Paulsen IT, -glycosylation and specific gut bacteria. Gut Microbes, 12(1):1802209(2020) [pubmed]

submitter keyword: - Dietary fibre modification, Liver proteome, C57BL/6J mice, Gut microbiota, short chain fatty acids, MUC2 glycosylation, Correlation network analysis

Mark Molloy
contact affiliation	Lawrence Penn Chair of Bowel Cancer Research, Faculty of Medicine and Health, The University of Sydney | Northern Clinical School
contact email	m.molloy@sydney.edu.au
lab head
Daniel BUCIO NOBLE
contact affiliation	Macquarie University
contact email	daniel.bucio-noble@students.mq.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD014132

PRIDE project URI

• PRIDE
  1. PXD014132
     1. Label: PRIDE project
     2. Name: Interactions between host and gut microbiota following dietary interventions