PXD014079
PXD014079 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Integrated multi-omics analysis of zinc deficiency |
Description | Zinc is an essential trace micronutrient and exerts important physiological and biochemical roles. Zinc deficiency is a global public-health problem. Standing untreated zinc deficiency can cause series adverse effects, including growth retardation, poor appetite, delayed sexual development, impaired neurologic and immune systems, diabetes and obesity, et al. However, the underlying mechanisms of these adverse effects remain elusive in most cases and a comprehensive understanding of the adverse effects (known and unknown) induced by zinc deficiency is lacking. As we know, zinc is a critical component of over 3000 enzymes and is required for numerous catalytic, structural, and regulatory functions of proteins. Thus, the impairments in enzyme actions are responsible for the gross symptoms of zinc deficiency. Altered enzymes may induce to the extensive changes in diverse molecular components of body, including DNA, mRNA and metabolites; and all above changes may work together to induce the adverse effects and affect the health of body. Therefore, protein changes associated with zinc deficiency are very necessary to be unraveled and described for revealing the known and unknown adverse effects and underlying mechanisms. In this project, we first performed a multi-omics study by integrating plasma metabolomics and proteomics, liver proteomics and metal ionomics on zinc deficient rats in order to identify biomarkers (proteins, metabolites and metal elements) of zinc deficiency and reveal the changed metabolic pathways. Eventually, we expected to completely present known adverse effects and their underlying molecular mechanisms, and uncover unknown adverse effects of zinc deficiency. |
HostingRepository | iProX |
AnnounceDate | 2019-06-05 |
AnnouncementXML | Submission_2023-08-27_21:08:19.638.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Maoqing Wang |
SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2019-05-31 00:11:09 | ID requested | |
⏵ 1 | 2023-08-27 21:08:21 | announced |
Publication List
Wang M, Fan L, Wei W, Wang P, Yu Q, Long Z, Sun Y, Li Z, Zi T, Dong F, Sun Z, Song X, Sun C, Li Y, Wang F, Integrated multi-omics uncovers reliable potential biomarkers and adverse effects of zinc deficiency. Clin Nutr, 40(5):2683-2696(2021) [pubmed] |
Keyword List
submitter keyword: Zinc deficiency,proteomics,TMT isobaric labeling |
Contact List
Maoqing Wang | |
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contact affiliation | National Key Disciplines of Nutrition and Food Hygiene, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China |
contact email | wang_maoqing@126.com |
lab head | |
Maoqing Wang | |
contact affiliation | National Key Disciplines of Nutrition and Food Hygiene, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China |
contact email | wang_maoqing@126.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |