PXD013978

PXD013978 is an original dataset announced via ProteomeXchange.

Title	Temporal multi-omics identifies LRG1 as vascular instructor of early metastatic colonization.
Description	Metastasis is the primary cause of cancer-related mortality and the mechanistically least well understood step of the tumor progression cascade. Employing surgical preclinical metastasis models, we show here that small primary tumors reprogram the body’s vascular endothelium to alter systemic homeostasis and to condition the premetastatic niche for metastatic colonization. Endothelial cells thereby serve as an amplifier of tumor-induced instructive signals. The combined endothelial transcriptomic and serum proteomic screen identified the TGFß pathway signaling specifier LRG1 as an early vascular niche instructor of metastatic colonization. Adjuvant LRG1 inhibition to primary tumor-resected mice delayed metastatic growth and increased overall survival. The study has thereby established the premetastatic systems map of primary tumor-induced vascular changes and identified LRG1 as a therapeutic target for metastasis
HostingRepository	PRIDE
AnnounceDate	2022-05-16
AnnouncementXML	Submission_2022-05-16_03:10:28.359.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bianca Kuhn
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-23 02:47:14	ID requested
⏵ 1	2022-05-16 03:10:29	announced

Singhal M, Gengenbacher N, Abdul Pari AA, Kamiyama M, Hai L, Kuhn BJ, Kallenberg DM, Kulkarni SR, Camilli C, Preu, ß SF, Leuchs B, Mogler C, Espinet E, Besemfelder E, Heide D, Heikenwalder M, Sprick MR, Trumpp A, Krijgsveld J, Schlesner M, Hu J, Moss SE, Greenwood J, Augustin HG, Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis. Sci Transl Med, 13(609):eabe6805(2021) [pubmed]

curator keyword: Biomedical

submitter keyword: Metastasis, LRG1, endothelial cells, Cancer, and Vascular niche

Prof. Dr. Hellmut Augustin
contact affiliation	Prof. Dr. Hellmut Augustin Vascular Oncology and Metastasis Deutsches Krebsforschungszentrum (DKFZ) Heidelberg
contact email	h.augustin@dkfz.de
lab head
Bianca Kuhn
contact affiliation	DKFZ Heidelbeg
contact email	bianca.kuhn@dkfz-heidelberg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD013978

PRIDE project URI

• PRIDE
  1. PXD013978
     1. Label: PRIDE project
     2. Name: Temporal multi-omics identifies LRG1 as vascular instructor of early metastatic colonization.