PXD013952

PXD013952 is an original dataset announced via ProteomeXchange.

Title	Bidirectional Control of Coronary Vascular Resistance by Eicosanoids via a Novel GPCR
Description	Arachidonic acid metabolites epoxyeicosatrienoates (EETs) and hydroxyeicosatetraenoates (HETEs) are important regulators of myocardial blood flow and coronary vascular resistance (CVR), but their mechanisms of action are not fully understood. We identified G protein-coupled receptor 39 (GPR39) as a microvascular smooth muscle cell (mVSMC) receptor antagonistically regulated by two endogenous eicosanoids: 15-HETE, which stimulates GPR39 to increase mVSMC intracellular calcium and augment microvascular CVR, and 14,15-EET, which inhibits these actions. Furthermore, zinc ion acts as an allosteric modulator of GPR39 to potentiate the efficacy of the two ligands. The study elucidates the roles of eicosanoids in cardiovascular physiology and disease and provide an opportunity for the development of novel GPR39-targeting therapies for cardiovascular disease.
HostingRepository	PRIDE
AnnounceDate	2022-04-13
AnnouncementXML	Submission_2022-04-13_03:33:53.093.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Phillip Wilmarth
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue
Instrument	LTQ; LTQ Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-21 05:21:32	ID requested
⏵ 1	2022-04-13 03:33:57	announced

Alkayed NJ, Cao Z, Qian ZY, Nagarajan S, Liu X, Nelson JW, Xie F, Li B, Fan W, Liu L, Grafe MR, Davis CM, Xiao X, Barnes AP, Kaul S, Control of coronary vascular resistance by eicosanoids via a novel GPCR. Am J Physiol Cell Physiol, 322(5):C1011-C1021(2022) [pubmed]

submitter keyword: Cardiovascular disease, G-coupled receptor 39, eicosanoids, microvascular smooth muscle cell, photoactive cross-linking, proteomics

Nabil J. Alkayed
contact affiliation	The Knight Cardiovascular Institute Oregon Health & Science University 3181 SW Sam Jackson Park Road Portland, OR 97239, USA
contact email	alkayedn@ohsu.edu
lab head
Phillip Wilmarth
contact affiliation	OHSU
contact email	wilmarth@ohsu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD013952

PRIDE project URI

• PRIDE
  1. PXD013952
     1. Label: PRIDE project
     2. Name: Bidirectional Control of Coronary Vascular Resistance by Eicosanoids via a Novel GPCR