PXD013876

PXD013876 is an original dataset announced via ProteomeXchange.

Title	Trypanosoma cruzi PAN 4 exosomes LC-MS/MS
Description	Here we report the proteome content of exosomes released by epimastigote and bloodstream trypomastigotes forms of T. cruzi, the aetiological agent of Chagas disease. The exosomes were isolated using the ultracentrifugation method and further processed for LC-MS/MS. The results showed differential proteomic profiles of this two forms with marked differences in surface molecules cargoes. Noteworthy, the trans-sialidase (TS) surface proteins, a family of polymorphic virulence factors were differentially expressed between insect and human stages of T. cruzi highlighting the different surface nature of this two parasite stages.
HostingRepository	PRIDE
AnnounceDate	2021-09-08
AnnouncementXML	Submission_2021-09-08_11:16:34.647.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD013876
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Luis Miguel de Pablos Torró
SpeciesList	scientific name: Trypanosoma cruzi strain CL Brener; NCBI TaxID: 353153;
ModificationList	Oxidation; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-16 05:18:44	ID requested
⏵ 1	2021-09-08 11:16:35	announced

Retana Moreira L, Prescilla-Ledezma A, Cornet-Gomez A, Linares F, J, ó, dar-Reyes AB, Fernandez J, Ibarrola Vannucci AK, De Pablos LM, Osuna A, . Int J Mol Sci, 22(10):(2021) [pubmed]

submitter keyword: Exosomes, Trypanosoma, epimastigote, trypomastigote

Dr. Antonio Osuna Carrillo de Albornoz
contact affiliation	Instituto de Biotecnología, Grupo de Bioquímica y Parasitología Molecular, Departamento de Parasitología, Universidad de Granada, Granada, Spain.
contact email	aosuna@ugr.es
lab head
Luis Miguel de Pablos Torró
contact affiliation	Universidad de Granada
contact email	lpablos@ugr.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD013876

PRIDE project URI

• PRIDE
  1. PXD013876
     1. Label: PRIDE project
     2. Name: Trypanosoma cruzi PAN 4 exosomes LC-MS/MS