PXD013835

PXD013835 is an original dataset announced via ProteomeXchange.

Title	Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation
Description	Migrasomes are recently identified vesicular organelles that form on retraction fibers behind migrating cells, cellular contents are released from migrasome by a process named migracytosis. The function of migrasomes in living organisms is unknown. Here we show that migrasomes are formed during zebrafish gastrulation, signaling molecules such as chemokines are enriched in migrasomes. Migrasomes are clustered on spatially restricted area in embryo where they provide regional cues for organ morphogenesis. Our study shown migrasome is signaling organelles which integrate spatial and specific biochemical information to coordinate migrating cells in complex biological processes such as morphogenesis.
HostingRepository	PRIDE
AnnounceDate	2019-06-03
AnnouncementXML	Submission_2019-08-08_03:23:12.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dong Jiang
SpeciesList	scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: 7955;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-14 02:13:39	ID requested
1	2019-06-03 05:57:31	announced
⏵ 2	2019-08-08 03:23:15	announced	Updated publication reference for PubMed record(s): 31371827.

Jiang D, Jiang Z, Lu D, Wang X, Liang H, Zhang J, Meng Y, Li Y, Wu D, Huang Y, Chen Y, Deng H, Wu Q, Xiong J, Meng A, Yu L, Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nat Cell Biol, 21(8):966-977(2019) [pubmed]

submitter keyword: migrasome, regional cue, morphogenesis

Li Yu
contact affiliation	Tsinghua University
contact email	liyulab@mail.tsinghua.edu.cn
lab head
Dong Jiang
contact affiliation	Tsinghua University
contact email	583417955@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/06/PXD013835

PRIDE project URI

• PRIDE
  1. PXD013835
     1. Label: PRIDE project
     2. Name: Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation