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PXD013785

PXD013785 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDynamic transcriptome-proteome correlation networks reveal human myeloid differentiation and neutrophil-specific programming
DescriptionHuman neutrophilic granulocytes form the largest pool of innate immune cells for host defense against bacterial and fungal pathogens. The dynamic changes that accompany the metamorphosis from a proliferating myeloid progenitor cell in the bone marrow into a mature non-dividing polymorphonuclear blood cell have remained poorly defined. Using mass spectrometry-based quantitative proteomics combined with transcriptomic data, we report on the dynamic changes of 5 developmental stages in the bone marrow and blood. Integration of transcriptomic and proteomic unveiled highly dynamic and differential interactions between RNA and protein kinetics during human neutrophil development which could be linked to functional maturation of typical end-stage blood neutrophil killing activities.
HostingRepositoryPRIDE
AnnounceDate2019-11-07
AnnouncementXMLSubmission_2020-09-28_00:22:45.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMaartje van den Biggelaar
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion ETD
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-05-09 06:27:30ID requested
12019-11-07 08:05:08announced
22020-09-28 00:22:46announced2020-09-28: Updated publication reference for PubMed record(s): 31747616.
Publication List
Hoogendijk AJ, Pourfarzad F, Aarts CEM, Tool ATJ, Hiemstra IH, Grassi L, Frontini M, Meijer AB, van den Biggelaar M, Kuijpers TW, Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming. Cell Rep, 29(8):2505-2519.e4(2019) [pubmed]
Keyword List
submitter keyword: Proteomics,Transcriptomics, neutriphils, myeloid differentiation
Contact List
M. van den Biggelaar
contact affiliationDepartment of Molecular and Cellular Hemostasis, Sanquin Research Amsterdam, NL
contact emailm.vandenbiggelaar@sanquin.nl
lab head
Maartje van den Biggelaar
contact affiliationSanquin Research
contact emailm.vandenbiggelaar@sanquin.nl
dataset submitter
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Dataset FTP location
PRIDE project URI
Repository Record List
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