PXD013777

PXD013777 is an original dataset announced via ProteomeXchange.

Title	Immunoglobulin V-gene usage among human serum IgA with or without specificity to the autoantigen transglutaminase 2
Description	To study V-gene usage among antigen-specific and non-antigen-specific serum IgA antibodies in celiac disease patients, purified antibody fractions were subjected to proteomic analysis. Patients either had eastablished, untreated disease with severe intestinal inflammation or "potential" celiac disease characterized by presence of antibodies but no or mild inflammation. Quantification of the fraction of antibodies using different IGHV segments revealed that antibodies specific to the autoantigen transglutaminase 2 (TG2) displayed a bias toward usage of IGHV5-51 in agreement with previous observations. The fraction of antibodies using IGHV5-51 correlated with the degree of intestinal inflammation, indicating that production of hallmark IGHV5-51 anti-TG2 antibodies coincides with onset of clinical celiac disease.
HostingRepository	PRIDE
AnnounceDate	2019-07-09
AnnouncementXML	Submission_2019-07-15_00:39:00.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rasmus Iversen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-08 09:06:45	ID requested
1	2019-07-09 02:34:49	announced
⏵ 2	2019-07-15 00:39:01	announced	Updated publication reference for PubMed record(s): 31285344.

Iversen R, Roy B, Stamnaes J, H, ø, ydahl LS, Hnida K, Neumann RS, Korponay-Szab, ó IR, Lundin KEA, Sollid LM, Efficient T cell-B cell collaboration guides autoantibody epitope bias and onset of celiac disease. Proc Natl Acad Sci U S A, 116(30):15134-15139(2019) [pubmed]

submitter keyword: Human, serum, IgA, celiac disease, autoantibodies

Ludvig M. Sollid
contact affiliation	KG Jebsen Coeliac Disease Research Centre, University of Oslo, NO-0372 Oslo, Norway
contact email	l.m.sollid@medisin.uio.no
lab head
Rasmus Iversen
contact affiliation	University of Oslo
contact email	rasmus.iversen@medisin.uio.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD013777

PRIDE project URI

• PRIDE
  1. PXD013777
     1. Label: PRIDE project
     2. Name: Immunoglobulin V-gene usage among human serum IgA with or without specificity to the autoantigen transglutaminase 2