PXD013730

PXD013730 is an original dataset announced via ProteomeXchange.

Title	Trrap-dependent lysine acetylation prevents neurodegeneration by modulating Sp1 transcriptional activity
Description	The acetylation levels of histones and other proteins change during aging and have been linked to neurodegeneration. Here we show that deletion of the histone acetyltransferase (HAT) co-factor Trrap specifically impairs the function of the transcription factor Sp1 and the recruitment of HATs to Sp1 target genes. Modulation of Sp1 function by Trrap acts as a hub regulating multiple processes involved in neuron and neural stem cells function and maintenance including microtubule dynamics and the Wnt signaling pathway. Consistently, Trrap conditional mutants exhibit all hallmarks of neurodegeneration including dendrite retraction and axonal swellings, neuron death, astrogliosis, microglia activation, demyelination and decreased adult neurogenesis. Our results uncovered a novel functional network, essential to prevent neurodegeneration, and involving the specific regulation of Sp1 transcription factor by Trrap-HAT.
HostingRepository	PRIDE
AnnounceDate	2021-03-02
AnnouncementXML	Submission_2021-03-02_22:27:23.943.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joanna Kirkpatrick
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-07 02:47:00	ID requested
1	2021-03-02 10:24:24	announced
⏵ 2	2021-03-02 22:27:24	announced	2021-03-03: Updated publication reference for PubMed record(s): 33594975.

Tapias A, L, á, zaro D, Yin BK, Rasa SMM, Krepelova A, Kelmer Sacramento E, Grigaravicius P, Koch P, Kirkpatrick J, Ori A, Neri F, Wang ZQ, HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration. Elife, 10():(2021) [pubmed]

submitter keyword: Neurodegeneration, Lysine acetylation, TRRAP, Wnt signalling, SP transcription factors

Zhao-Qi Wang
contact affiliation	Leibniz Institute on Aging Fritz Lipmann Institute (FLI) Beutenbergstrasse 11 07745 Jena Germany
contact email	Zhao-Qi.Wang@leibniz-fli.de
lab head
Joanna Kirkpatrick
contact affiliation	Leibniz Institute on Aging - FLI
contact email	joanna.kirkpatrick@leibniz-fli.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/03/PXD013730

PRIDE project URI

• PRIDE
  1. PXD013730
     1. Label: PRIDE project
     2. Name: Trrap-dependent lysine acetylation prevents neurodegeneration by modulating Sp1 transcriptional activity