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PXD013721 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development-2
DescriptionThe senescence-associated secretory phenotype (SASP) has recently emerged as both a driver of -- and promising therapeutic target for -- a multitude of chronic age-related conditions, ranging from neurodegeneration to cancer. The complexity of the SASP, typically monitored by the secretion of a few proteins, has been greatly underappreciated, and a small set of factors cannot explain the diverse phenotypes it produces in vivo. Here, we present SASP Atlas, a comprehensive proteomic database of SASPs driven by multiple inducers of senescence in different human cell types. While there are common elements among all the SASPs we have documented so far, we discovered distinct senescence inducer- and cell type-specific secretory proteins. In all cases, the SASPs are comprised of hundreds of unique proteins secreted as both soluble proteins (sSASP) and exosomes (eSASP) with distinct and novel protein profiles. This resource will aid in identifying the proteins that drive senescence-associated phenotypes and provide comprehensive catalogs of potential senescence biomarkers that can be used to assess the burden and the originating stimuli and type of senescent cells in vivo.
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListOxidation; Carbamidomethyl
InstrumentTripleTOF 5600; TripleTOF 6600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-05-06 13:34:56ID requested
12019-05-06 16:56:13announced
Publication List
no publication
Keyword List
submitter keyword: senescence, data-independent acquisition, secretome, sasp, senescence-associated secretory phenotype, aging, biomarker
Contact List
Birgit Schilling
contact affiliationThe Buck Institute for Research on Aging
contact emailbschilling@buckinstitute.org
lab head
contact affiliationThe Buck Institute for Research on Aging
contact emailnbasisty@buckinstitute.org
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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