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PXD013688

PXD013688 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleExtracellular vesicles impose quiescence and confer DNA-damage on residual HSC in the AML niche
DescriptionTo understand the mechanism by which AML-EVs may enforce quiescence, we performed tandem mass tag (TMT) proteomic profiling of in vitro cultured c-Kit+ hematopoietic stem and progenitor cells (HSPC) (to obtain the minimum required amount of protein lysates) treated with extracellular vesicles (EVs) for 48 hours from human HL-60 or Molm-14 cell cultures versus controls.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:55:05.070.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPhillip Wilmarth
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue
InstrumentOrbitrap Fusion ETD
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-05-02 01:33:07ID requested
12019-06-24 03:51:16announced
22024-10-22 04:55:07announced2024-10-22: Updated project metadata.
Publication List
10.15252/embr.201847546;
Keyword List
submitter keyword: AML-derived extracellular vesicles, isobaric labeling, proteomics, bone marrow,acute myeloid leukemia (AML), mouse, tandem mass tags
Contact List
Dr. Peter Kurre
contact affiliationProfessor of Pediatrics Children’s Hospital of Philadelphia 3615 Civic Center Blvd Philadelphia, PA 19104
contact emailkurrep@email.chop.edu
lab head
Phillip Wilmarth
contact affiliationOHSU
contact emailwilmarth@ohsu.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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