PXD013688 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Extracellular vesicles impose quiescence and confer DNA-damage on residual HSC in the AML niche |
Description | To understand the mechanism by which AML-EVs may enforce quiescence, we performed tandem mass tag (TMT) proteomic profiling of in vitro cultured c-Kit+ hematopoietic stem and progenitor cells (HSPC) (to obtain the minimum required amount of protein lysates) treated with extracellular vesicles (EVs) for 48 hours from human HL-60 or Molm-14 cell cultures versus controls. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:55:05.070.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Phillip Wilmarth |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue |
Instrument | Orbitrap Fusion ETD |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-05-02 01:33:07 | ID requested | |
1 | 2019-06-24 03:51:16 | announced | |
⏵ 2 | 2024-10-22 04:55:07 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: AML-derived extracellular vesicles, isobaric labeling, proteomics, bone marrow,acute myeloid leukemia (AML), mouse, tandem mass tags |
Contact List
Dr. Peter Kurre |
contact affiliation | Professor of Pediatrics Children’s Hospital of Philadelphia 3615 Civic Center Blvd Philadelphia, PA 19104 |
contact email | kurrep@email.chop.edu |
lab head | |
Phillip Wilmarth |
contact affiliation | OHSU |
contact email | wilmarth@ohsu.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/06/PXD013688 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013688
- Label: PRIDE project
- Name: Extracellular vesicles impose quiescence and confer DNA-damage on residual HSC in the AML niche