PXD013688

PXD013688 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Extracellular vesicles impose quiescence and confer DNA-damage on residual HSC in the AML niche
Description	To understand the mechanism by which AML-EVs may enforce quiescence, we performed tandem mass tag (TMT) proteomic profiling of in vitro cultured c-Kit+ hematopoietic stem and progenitor cells (HSPC) (to obtain the minimum required amount of protein lysates) treated with extracellular vesicles (EVs) for 48 hours from human HL-60 or Molm-14 cell cultures versus controls.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:55:05.070.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Phillip Wilmarth
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue
Instrument	Orbitrap Fusion ETD

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-02 01:33:07	ID requested
1	2019-06-24 03:51:16	announced
⏵ 2	2024-10-22 04:55:07	announced	2024-10-22: Updated project metadata.

Publication List

10.15252/embr.201847546;

10.15252/embr.201847546;

Keyword List

submitter keyword: AML-derived extracellular vesicles, isobaric labeling, proteomics, bone marrow,acute myeloid leukemia (AML), mouse, tandem mass tags

submitter keyword: AML-derived extracellular vesicles, isobaric labeling, proteomics, bone marrow,acute myeloid leukemia (AML), mouse, tandem mass tags

Contact List

Dr. Peter Kurre
contact affiliation	Professor of Pediatrics Children’s Hospital of Philadelphia 3615 Civic Center Blvd Philadelphia, PA 19104
contact email	kurrep@email.chop.edu
lab head
Phillip Wilmarth
contact affiliation	OHSU
contact email	wilmarth@ohsu.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/06/PXD013688
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/06/PXD013688

PRIDE project URI

Repository Record List

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