PXD013683

PXD013683 is an original dataset announced via ProteomeXchange.

Title	Identification of histone adducts with glycidamide
Description	Identification of protein covalent modifications (adducts) is a challenging task mainly due to the lack of data processing approaches for Adductomics studies. We report a novel strategy to identify covalently modified peptides that consists on LC-MS data preprocessing followed by statistical analysis. This strategy was compared with the standard methodology of adductomics, which relies on producing comprehensive MS/MS data by data dependent acquisition and analysis with proteomics data search engines (Mascot, Global Proteome Machine interface (GPM Fury) that uses X!Tandem, MaxQuant and MSFragger).
HostingRepository	PRIDE
AnnounceDate	2019-07-25
AnnouncementXML	Submission_2019-08-22_01:34:32.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD013683
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Judit Morello
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Glycidamide
Instrument	impact II

Revision	Datetime	Status	ChangeLog Entry
0	2019-05-01 05:55:42	ID requested
1	2019-07-25 08:34:35	announced
⏵ 2	2019-08-22 01:44:53	announced	Updated publication reference for PubMed record(s): 31417895.

Nunes J, Charneira C, Nunes C, Gouveia-Fernandes S, Serpa J, Morello J, Antunes AMM, A Metabolomics-Inspired Strategy for the Identification of Protein Covalent Modifications. Front Chem, 7():532(2019) [pubmed]

submitter keyword: Glycidamide, histones, mass spectrometry, adductomics

Alexandra MM Antunes
contact affiliation	Centro de Química Estrutural, Instituto Superior Técnico, ULisboa, Lisboa, Portugal
contact email	alexandra.antunes@tecnico.ulisboa.pt
lab head
Judit Morello
contact affiliation	CQE, IST
contact email	judit.morello@tecnico.ulisboa.pt
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD013683

PRIDE project URI

• PRIDE
  1. PXD013683
     1. Label: PRIDE project
     2. Name: Identification of histone adducts with glycidamide