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PXD013683

PXD013683 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of histone adducts with glycidamide
DescriptionIdentification of protein covalent modifications (adducts) is a challenging task mainly due to the lack of data processing approaches for Adductomics studies. We report a novel strategy to identify covalently modified peptides that consists on LC-MS data preprocessing followed by statistical analysis. This strategy was compared with the standard methodology of adductomics, which relies on producing comprehensive MS/MS data by data dependent acquisition and analysis with proteomics data search engines (Mascot, Global Proteome Machine interface (GPM Fury) that uses X!Tandem, MaxQuant and MSFragger).
HostingRepositoryPRIDE
AnnounceDate2019-07-25
AnnouncementXMLSubmission_2019-08-22_01:34:32.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD013683
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterJudit Morello
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListOxidation; Glycidamide
Instrumentimpact II
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-05-01 05:55:42ID requested
12019-07-25 08:34:35announced
22019-08-22 01:44:53announcedUpdated publication reference for PubMed record(s): 31417895.
Publication List
Nunes J, Charneira C, Nunes C, Gouveia-Fernandes S, Serpa J, Morello J, Antunes AMM, A Metabolomics-Inspired Strategy for the Identification of Protein Covalent Modifications. Front Chem, 7():532(2019) [pubmed]
Keyword List
submitter keyword: Glycidamide, histones, mass spectrometry, adductomics
Contact List
Alexandra MM Antunes
contact affiliationCentro de Química Estrutural, Instituto Superior Técnico, ULisboa, Lisboa, Portugal
contact emailalexandra.antunes@tecnico.ulisboa.pt
lab head
Judit Morello
contact affiliationCQE, IST
contact emailjudit.morello@tecnico.ulisboa.pt
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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