PXD013672 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Hypoxic regulation of the inflammatory lung neutrophil proteome |
Description | This project aimed to define the proteome of inflammatory lung neutrophils and determine how his is regulated by exposure to in vivo hypoxia. An acute lung injury was induced using nebulised LPS. Following LPS administration mice were housed in either normal room air or in a hypoxic chamber set at an inspired oxygen concentration of 10%. Highly pure bronchoalveolar lavage (BAL) neutrophils were isolated from the lungs of C57Bl6 mice 24 hours after being treated with LPS. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:20:58.451.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Emily Watts |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-04-30 03:15:14 | ID requested | |
1 | 2021-04-07 23:57:47 | announced | |
⏵ 2 | 2024-10-22 05:21:01 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1172/jci134073; |
Watts ER, Howden AJ, Morrison T, Sadiku P, Hukelmann J, von Kriegsheim A, Ghesquiere B, Murphy F, Mirchandani AS, Humphries DC, Grecian R, Ryan EM, Coelho P, Blanco GR, Plant TM, Dickinson RS, Finch A, Vermaelen W, Cantrell DA, Whyte MK, Walmsley SR, Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism. J Clin Invest, 131(10):(2021) [pubmed] |
Keyword List
submitter keyword: inflammation, hypoxia, lung,Neutrophil |
Contact List
Sarah Ruth Walmsley |
contact affiliation | The University of Edinburgh/ Centre for Inflammation Research The Queen's Medical Research Institute Edinburgh BioQuarter 47 Little France Crescent Edinburgh EH16 4TJ |
contact email | sarah.walmsley@ed.ac.uk |
lab head | |
Emily Watts |
contact affiliation | University of Edinburgh |
contact email | emily.watts@ed.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD013672 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013672
- Label: PRIDE project
- Name: Hypoxic regulation of the inflammatory lung neutrophil proteome