PXD013672

PXD013672 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Hypoxic regulation of the inflammatory lung neutrophil proteome
Description	This project aimed to define the proteome of inflammatory lung neutrophils and determine how his is regulated by exposure to in vivo hypoxia. An acute lung injury was induced using nebulised LPS. Following LPS administration mice were housed in either normal room air or in a hypoxic chamber set at an inspired oxygen concentration of 10%. Highly pure bronchoalveolar lavage (BAL) neutrophils were isolated from the lungs of C57Bl6 mice 24 hours after being treated with LPS.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:20:58.451.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Emily Watts
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-30 03:15:14	ID requested
1	2021-04-07 23:57:47	announced
⏵ 2	2024-10-22 05:21:01	announced	2024-10-22: Updated project metadata.

Publication List

10.1172/jci134073;
Watts ER, Howden AJ, Morrison T, Sadiku P, Hukelmann J, von Kriegsheim A, Ghesquiere B, Murphy F, Mirchandani AS, Humphries DC, Grecian R, Ryan EM, Coelho P, Blanco GR, Plant TM, Dickinson RS, Finch A, Vermaelen W, Cantrell DA, Whyte MK, Walmsley SR, Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism. J Clin Invest, 131(10):(2021) [pubmed]

10.1172/jci134073;

Watts ER, Howden AJ, Morrison T, Sadiku P, Hukelmann J, von Kriegsheim A, Ghesquiere B, Murphy F, Mirchandani AS, Humphries DC, Grecian R, Ryan EM, Coelho P, Blanco GR, Plant TM, Dickinson RS, Finch A, Vermaelen W, Cantrell DA, Whyte MK, Walmsley SR, Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism. J Clin Invest, 131(10):(2021) [pubmed]

Keyword List

submitter keyword: inflammation, hypoxia, lung,Neutrophil

submitter keyword: inflammation, hypoxia, lung,Neutrophil

Contact List

Sarah Ruth Walmsley
contact affiliation	The University of Edinburgh/ Centre for Inflammation Research The Queen's Medical Research Institute Edinburgh BioQuarter 47 Little France Crescent Edinburgh EH16 4TJ
contact email	sarah.walmsley@ed.ac.uk
lab head
Emily Watts
contact affiliation	University of Edinburgh
contact email	emily.watts@ed.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD013672
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD013672

PRIDE project URI

Repository Record List

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