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PXD013672

PXD013672 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHypoxic regulation of the inflammatory lung neutrophil proteome
DescriptionThis project aimed to define the proteome of inflammatory lung neutrophils and determine how his is regulated by exposure to in vivo hypoxia. An acute lung injury was induced using nebulised LPS. Following LPS administration mice were housed in either normal room air or in a hypoxic chamber set at an inspired oxygen concentration of 10%. Highly pure bronchoalveolar lavage (BAL) neutrophils were isolated from the lungs of C57Bl6 mice 24 hours after being treated with LPS.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:20:58.451.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterEmily Watts
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-04-30 03:15:14ID requested
12021-04-07 23:57:47announced
22024-10-22 05:21:01announced2024-10-22: Updated project metadata.
Publication List
10.1172/jci134073;
Watts ER, Howden AJ, Morrison T, Sadiku P, Hukelmann J, von Kriegsheim A, Ghesquiere B, Murphy F, Mirchandani AS, Humphries DC, Grecian R, Ryan EM, Coelho P, Blanco GR, Plant TM, Dickinson RS, Finch A, Vermaelen W, Cantrell DA, Whyte MK, Walmsley SR, Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism. J Clin Invest, 131(10):(2021) [pubmed]
Keyword List
submitter keyword: inflammation, hypoxia, lung,Neutrophil
Contact List
Sarah Ruth Walmsley
contact affiliationThe University of Edinburgh/ Centre for Inflammation Research The Queen's Medical Research Institute Edinburgh BioQuarter 47 Little France Crescent Edinburgh EH16 4TJ
contact emailsarah.walmsley@ed.ac.uk
lab head
Emily Watts
contact affiliationUniversity of Edinburgh
contact emailemily.watts@ed.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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