PXD013648

PXD013648 is an original dataset announced via ProteomeXchange.

Title	The equine granulocyte proteome: expression changes in autoimmune disease and after stimulation
Description	We investigated the granulocyte proteome from healthy horses, horses with a spontaneous autoimmune disease (equine recurrent uveitis) and the reaction of granulocytes to different stimuli (IL8, PMA, LPS) on protein level. A total of 2032 proteins describing the whole granulocyte proteome were identified, including 245 proteins (12% of proteome) newly associated to in vivo expression in primary granulocytes (hypothetical proteins). Our studies provide novel information on the granulocyte proteome and contribute to a better understanding of molecular mechanisms involved in activation and recruitment of neutrophils and the role of these cells in modulating and regulating autoimmune diseases. The data presented here is highly relevant for veterinary medicine and has translational quality for spontaneous autoimmune uveitis in man.
HostingRepository	PRIDE
AnnounceDate	2020-01-15
AnnouncementXML	Submission_2020-02-17_01:10:07.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roxane Degroote
SpeciesList	scientific name: Equus caballus (Horse); NCBI TaxID: 9796;
ModificationList	deaminated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-26 03:43:23	ID requested
1	2020-01-15 07:50:08	announced
⏵ 2	2020-02-17 01:10:08	announced	2020-02-17: Updated publication reference for PubMed record(s): 32010136.

Degroote RL, Weigand M, Hauck SM, Deeg CA, IL8 and PMA Trigger the Regulation of Different Biological Processes in Granulocyte Activation. Front Immunol, 10():3064(2019) [pubmed]

curator keyword: Biological

submitter keyword: granulocyte, autoimmune disease, IL8

Cornelia A Deeg
contact affiliation	LMU Munich, Chair of Animal Physiology
contact email	deeg@tiph.vetmed.uni-muenchen.de
lab head
Roxane Degroote
contact affiliation	Ludwig-Maximilians-University Munich, Chair of Animal Physiology, Veterinaerstrasse 13, 80539, Munich, Germany
contact email	r.degroote@lmu.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD013648
     1. Label: PRIDE project
     2. Name: The equine granulocyte proteome: expression changes in autoimmune disease and after stimulation