PXD013647

PXD013647 is an original dataset announced via ProteomeXchange.

Title	The tumor suppressor SCRIB is a negative modulator of the Wnt/-catenin signaling (part 1)
Description	Epithelial tissues are highly organized structures that rely on cell polarity pathways driven by membrane receptors and scaffolding proteins. SCRIBBLE is a cytoplasmic scaffold present at cell-cell junctions in polarized cells that contains LRR and PDZ domains as its paralogue LANO, a member of the LAP protein family. The family is composed of DENSIN-180, ERBIN, SCRIB and LRRC1. Based on phylogenic tree, LAP proteins can be split in two branches with the first branch is made up with SCRIB and LRCC1 and the second one of ERBIN and DENSIN-180. The current interactome of SCRIB and LRRC1 consists of 67 and 30 protein interaction partners respectively with only 9 (10%) common partners (BioGRID, version 3.5). Our study uncovers the proteome associated to SCRIB and LRRC1 and described for the first time protein associated to each paralogue.
HostingRepository	PRIDE
AnnounceDate	2019-09-25
AnnouncementXML	Submission_2019-09-25_09:56:13.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luc Camoin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-26 03:29:39	ID requested
⏵ 1	2019-09-25 09:56:14	announced

Daulat AM, Wagner MS, Walton A, Baudelet E, Audebert S, Camoin L, Borg JP, -Catenin Signaling Pathway. Proteomics, 19(21-22):e1800487(2019) [pubmed]

submitter keyword: SCRIB

LRRC1

proteomics analysis

Luc Camoin
contact affiliation	Inserm, CBRS, Ais Marseille University, CRCM, Marseille Proteomics
contact email	luc.camoin@inserm.fr
lab head
Luc Camoin
contact affiliation	Life Sciences
contact email	luc.camoin@inserm.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/09/PXD013647

PRIDE project URI

• PRIDE
  1. PXD013647
     1. Label: PRIDE project
     2. Name: The tumor suppressor SCRIB is a negative modulator of the Wnt/-catenin signaling (part 1)