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PXD013622

DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2019-06-12
  • AnnouncementXML: Submission_2019-06-12_07:18:34.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Wenguang Shao
  • Title: Comparative analysis of mRNA degradation and protein degradation in prostate tissues indicates high stability of proteins
  • Description: To benchmark the PIN algorithm that quantifies the extent of protein degradation in samples, we generated a set of “ground truth” samples, in which the levels of proteome degradation were known and independently validated by western blotting. Protein extracts of HeLa Kyoto cells were treated with the low specificity protease Proteinase K at different protease concentrations.
  • SpeciesList: scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
  • ModificationList: No PTMs are included in the dataset
  • Instrument: TripleTOF 5600

Dataset History

VersionDatetimeStatusChangeLog Entry
02019-04-24 07:52:52ID requested
12019-06-12 07:18:35announced

Publication List

  1. Shao W, Guo T, Toussaint NC, Xue P, Wagner U, Li L, Charmpi K, Zhu Y, Wu J, Buljan M, Sun R, Rutishauser D, Hermanns T, Fankhauser CD, Poyet C, Ljubicic J, Rupp N, Rüschoff JH, Zhong Q, Beyer A, Ji J, Collins BC, Liu Y, Rätsch G, Wild PJ, Aebersold R, Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins. Nat Commun, 10(1):2524(2019) [pubmed]

Keyword List

  1. submitter keyword: Benchmarking
  2. Proteome Integrity

Contact List

    Ruedi Aebersold
    • contact affiliation: Institute of Molecular Systems Biology, ETH Zurich, Switzerland
    • contact email: aebersold@imsb.biol.ethz.ch
    • lab head:
    Wenguang Shao
    • contact affiliation: ETH Zurich
    • contact email: shaowenguang@gmail.com
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List
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