PXD013622

PXD013622 is an original dataset announced via ProteomeXchange.

Title	Comparative analysis of mRNA degradation and protein degradation in prostate tissues indicates high stability of proteins
Description	To benchmark the PIN algorithm that quantifies the extent of protein degradation in samples, we generated a set of “ground truth” samples, in which the levels of proteome degradation were known and independently validated by western blotting. Protein extracts of HeLa Kyoto cells were treated with the low specificity protease Proteinase K at different protease concentrations.
HostingRepository	PRIDE
AnnounceDate	2019-06-12
AnnouncementXML	Submission_2019-06-12_07:18:34.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wenguang Shao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-24 07:52:52	ID requested
⏵ 1	2019-06-12 07:18:35	announced

Shao W, Guo T, Toussaint NC, Xue P, Wagner U, Li L, Charmpi K, Zhu Y, Wu J, Buljan M, Sun R, Rutishauser D, Hermanns T, Fankhauser CD, Poyet C, Ljubicic J, Rupp N, R, ü, schoff JH, Zhong Q, Beyer A, Ji J, Collins BC, Liu Y, R, ä, tsch G, Wild PJ, Aebersold R, Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins. Nat Commun, 10(1):2524(2019) [pubmed]

submitter keyword: Benchmarking

Proteome Integrity

Ruedi Aebersold
contact affiliation	Institute of Molecular Systems Biology, ETH Zurich, Switzerland
contact email	aebersold@imsb.biol.ethz.ch
lab head
Wenguang Shao
contact affiliation	ETH Zurich
contact email	shaowenguang@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/06/PXD013622

PRIDE project URI

• PRIDE
  1. PXD013622
     1. Label: PRIDE project
     2. Name: Comparative analysis of mRNA degradation and protein degradation in prostate tissues indicates high stability of proteins