PXD013584

PXD013584 is an original dataset announced via ProteomeXchange.

Title	CEH-60/PBX regulates vitellogenesis and cuticle formation through interaction with UNC-62/MEIS in Caenorhabditis elegans
Description	The onset of sexual maturity involves dramatic changes in physiology and gene expression in many animals. A textbook example is the production of enormous amounts of yolk proteins destined for the nascent oocytes, termed vitellogenesis. We previously identified the rapidly evolving PBC-class Hox-cofactor CEH-60/PBX as necessary for abundant vit transcription in C. elegans. Differential proteomics data shows that all vitellogenin proteins are indeed drastically downregulated in ceh-60 mutant animals and suggest an additional role for CEH-60’s involvement cuticle structure, innate immunity and stress response.
HostingRepository	PRIDE
AnnounceDate	2019-09-25
AnnouncementXML	Submission_2019-11-12_23:32:24.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pieter Van de Walle
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-23 01:13:59	ID requested
1	2019-09-25 07:04:08	announced
⏵ 2	2019-11-12 23:32:26	announced	2019-11-13: Updated publication reference for PubMed record(s): 31675356.

Van de Walle P, Geens E, Baggerman G, Jos, é, Naranjo-Galindo F, Askjaer P, Schoofs L, Temmerman L, CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans. PLoS Biol, 17(11):e3000499(2019) [pubmed]

submitter keyword: Caenorhabditis elegans, CEH-60, vitellogenesis, yolk proteins, cuticle, collagen, TMT

Liesbet Temmerman
contact affiliation	Department of Biology, KU Leuven (University of Leuven), Belgium ( lab head )
contact email	liesbet.temmerman@kuleuven.be
lab head
Pieter Van de Walle
contact affiliation	KU Leuven
contact email	pietervandwalle@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/09/PXD013584

PRIDE project URI

• PRIDE
  1. PXD013584
     1. Label: PRIDE project
     2. Name: CEH-60/PBX regulates vitellogenesis and cuticle formation through interaction with UNC-62/MEIS in Caenorhabditis elegans