PXD013543

PXD013543 is an original dataset announced via ProteomeXchange.

Title	Myocardial proteome from obese rats with cardiac dysfunction C4PR_LIV
Description	Obesity is a complex metabolic disease considered a global pandemic and associated with high incidence of cardiovascular disease. The excess of adipose tissue may promotes maladaptation that result in alterations in structure and function of the heart; however, the mechanisms are not fully elucidated. Proteomics may provide a deeper understanding into the pathophysiological process and contribute to the identification of new potential therapeutic targets. Thus, the aim of this was evaluate the myocardial protein expression in healthy and obese rats induced by Western diet to better comprehend the network of mechanisms inherent to cardiac dysfunction in obesity. For this purpose, we performed proteomic approaches based on nano-liquid chromatography-tandem mass spectrometry (nLC-MS/MS) followed by label-free quantification.
HostingRepository	PRIDE
AnnounceDate	2019-12-04
AnnouncementXML	Submission_2020-01-14_23:48:58.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD013543
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Danielle Vileigas
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-17 07:32:47	ID requested
1	2019-12-04 01:04:28	announced
⏵ 2	2020-01-14 23:49:00	announced	2020-01-15: Updated publication reference for PubMed record(s): 31792287.

Vileigas DF, Harman VM, Freire PP, Marciano CLC, Sant'Ana PG, de Souza SLB, Mota GAF, da Silva VL, Campos DHS, Padovani CR, Okoshi K, Beynon RJ, Santos LD, Cicogna AC, Landscape of heart proteome changes in a diet-induced obesity model. Sci Rep, 9(1):18050(2019) [pubmed]

submitter keyword: Rattus norvegicus, heart tissue, nLC-MS/MS, Q Exactive, shotgun proteomic

Antonio Carlos Cicogna
contact affiliation	Sao Paulo State University Medical School Av. Prof. Mário Rubens Guimarães Montenegro, s/n 18618-687 Botucatu, São Paulo, Brazil.
contact email	ac.cicogna@unesp.br
lab head
Danielle Vileigas
contact affiliation	UNESP
contact email	dani.vileigas@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/12/PXD013543

PRIDE project URI

• PRIDE
  1. PXD013543
     1. Label: PRIDE project
     2. Name: Myocardial proteome from obese rats with cardiac dysfunction C4PR_LIV