PXD013434

PXD013434 is an original dataset announced via ProteomeXchange.

Title	The long noncoding RNA neuroLNC modulates neurotransmitter release interacting with a neurodegeneration-associated protein
Description	The roles of long noncoding RNAs (lncRNAs) in synaptic transmission and neuronal development are emerging. Here we applied an integrated bioinformatic/biological screening strategy to identify lncRNAs that regulate synaptic vesicle release. We identified neuroLNC, a conserved neuron-specific nuclear lncRNA that modulates synaptic vesicle release, presynaptic calcium influx, neurite elongation and neuronal migration. In neurons neuroLNC interacts with a neurodegeneration-associated protein and tunes a set of presynaptic transcripts implicated in neurotransmitter release.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:05:15.230.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sunit Mandad
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-10 00:29:17	ID requested
1	2020-05-26 14:07:47	announced
⏵ 2	2024-10-22 05:05:21	announced	2024-10-22: Updated project metadata.

Keihani S, Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, Gomes LC, G, ä, rtner A, K, ü, gler S, Urlaub H, Wren JD, Bonn S, Rizzoli SO, Fornasiero EF, regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43. Sci Adv, 5(12):eaay2670(2019) [pubmed]

10.1126/sciadv.aay2670;

curator keyword: Biological

submitter keyword: neuron, ELLPs, cerebellum, metabolic labeling, brain turnover, cortex,Protein lifetimes, glia

Eugenio F. Fornasiero
contact affiliation	Department of Neuro- and Sensory Physiology University Medical Center Göttingen Humboldtallee 23 37073 Göttingen
contact email	efornas@gwdg.de
lab head
Sunit Mandad
contact affiliation	University Medical Centre Göttingen, Georg-August-Universität
contact email	smandad@gwdg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD013434

PRIDE project URI

• PRIDE
  1. PXD013434
     1. Label: PRIDE project
     2. Name: The long noncoding RNA neuroLNC modulates neurotransmitter release interacting with a neurodegeneration-associated protein