PXD013412

PXD013412 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis of the Enterobacter cloacae response to imipenem
Description	Recently, we have reported on a highly drug-resistant carbapenemase-producing isolate of Enterobacter cloacae (Nepal et al., Virulence. 2018; 9: 1377-1389). In the present study, we asked the question whether and, if so, how this isolate responds to a sub-inhibitory challenge with the antibiotic imipenem. To answer this question, we applied a SILAC proteomics approach that allowed the quantification of changes in the relative abundance of bacterial protein in response to imipenem. The results show that the investigated E. cloacae isolate mounts a highly specific response to counteract the detrimental effects of imipenem.
HostingRepository	PRIDE
AnnounceDate	2021-08-10
AnnouncementXML	Submission_2021-08-10_06:49:16.579.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sandra Maass
SpeciesList	scientific name: Enterobacter cloacae; NCBI TaxID: 550;
ModificationList	monohydroxylated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-09 01:24:12	ID requested
1	2021-08-10 03:53:01	announced
⏵ 2	2021-08-10 06:49:17	announced	2021-08-10: Updated project metadata.

Nepal S, Maa, ß S, Grasso S, Cavallo FM, Bartel J, Becher D, Bathoorn E, van Dijl JM, Isolate. Antibiotics (Basel), 10(5):(2021) [pubmed]

10.3390/ANTIBIOTICS10050501;

curator keyword: Biomedical

submitter keyword: Enterobacter cloacae, drug resistance, anitbiotic, imipenem, Proteomics

Dörte Becher
contact affiliation	University of Greifswald Institute of Microbiology Department of Microbial Proteomics Felix-Hausdorff-Str. 8 17489 Greifswald
contact email	dbecher@uni-greifswald.de
lab head
Sandra Maass
contact affiliation	University of Greifswald, Department for Microbial Proteomics
contact email	sandra.maass@uni-greifswald.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/08/PXD013412

PRIDE project URI

• PRIDE
  1. PXD013412
     1. Label: PRIDE project
     2. Name: Proteomics analysis of the Enterobacter cloacae response to imipenem