PXD013401

PXD013401 is an original dataset announced via ProteomeXchange.

Title	Functions of the FtsH1/3 complex in the nutrient stress response of Synechocystis
Description	FtsH zinc metalloproteinases are membrane-intrinsic and occur in bacteria, chloroplasts, and mitochondria. They are involved in diverse cellular processes including protein quality control and regulation. The cyanobacterium Synechocystis possesses four FtsH homologs, designated FtsH1-4 which function as both homo- and hetero-oligomeric complexes. For example, the FtsH1/3 complex is known to have a critical role in iron homeostasis. This project is aimed at the investigation of the involvement of the FtsH1/3 complex in cyanobacterial responses to nitrogen, phosphate and inorganic carbon starvation. By proteomic comparisons of the effects of these nutrient stresses in WT and an FtsH1-down mutant, we demonstrate significant differences in the abundances of transcription factors that complement the responses to nutrient stress at the transcriptome level. We propose a mechanism of epistatic regulation of stress-response gene expression by FtsH1/3 complex-mediated degradation of suppressor transcription factors.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:24:32.818.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Philip Jackson
SpeciesList	scientific name: Synechocystis sp. (strain PCC 6803 / Kazusa); NCBI TaxID: 1111708;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-08 07:01:25	ID requested
1	2021-08-13 05:33:19	announced
2	2021-08-15 23:58:31	announced	2021-08-16: Updated project metadata.
⏵ 3	2024-10-22 05:24:34	announced	2024-10-22: Updated project metadata.

Krynick, á V, Georg J, Jackson PJ, Dickman MJ, Hunter CN, Futschik ME, Hess WR, Komenda J, sp strain PCC 6803. Plant Cell, 31(12):2912-2928(2019) [pubmed]

10.1105/tpc.19.00411;

submitter keyword: nutrient stress, FtsH,Synechocystis, transcription factors

Joseph Komenda
contact affiliation	Centre Algatech, Institute of Microbiology, Academy of Sciences of the Czech Republic, 6 Novohradská 237, Třeboň, 379 81, Czech Republic
contact email	komenda@alga.cz
lab head
Philip Jackson
contact affiliation	School of Biosciences, University of Sheffield
contact email	p.j.jackson@sheffield.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD013401
     1. Label: PRIDE project
     2. Name: Functions of the FtsH1/3 complex in the nutrient stress response of Synechocystis