PXD013386

PXD013386 is an original dataset announced via ProteomeXchange.

Title	Metaproteomics characterizes human gut microbiota function in colorectal cancer
Description	Alterations in gut microbiota have been implicated in the pathogenesis of Colorectal Cancer (CRC). Here we collected fecal samples from 14 CRC patients and 14 healthy volunteer cohorts, and characterized their microbiota using label-free quantitative metaproteomics method. We have quantified 30,062 gut microbial protein groups, 91，902 peptides, and 195 genera of microbes, among which 341 proteins were found significantly different in abundance between the CRC patients and healthy volunteers. Our study demonstrates that gut bacteria involve in CRC pathogenesis not only via taxonomy abundance variations but also functional activity changes.
HostingRepository	iProX
AnnounceDate	2020-02-23
AnnouncementXML	Submission_2021-09-23_19:58:12.668.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi Yang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-05 23:29:43	ID requested
1	2020-02-22 22:25:59	announced
⏵ 2	2021-09-23 19:58:13	announced	2021-06-03: Update publication Informatica.

Long S, Yang Y, Shen C, Wang Y, Deng A, Qin Q, Qiao L, Metaproteomics characterizes human gut microbiome function in colorectal cancer. NPJ Biofilms Microbiomes, 6(1):14(2020) [pubmed]

submitter keyword: metaproteomics, microbiota, colorectal cancer, DIA

Liang Qiao
contact affiliation	Department of Chemistry, Shanghai Stomatological Hospital, Fudan University
contact email	liang_qiao@fudan.edu.cn
lab head
Yi Yang
contact affiliation	Department of Chemistry, Fudan University
contact email	13307110210@fudan.edu.cn
dataset submitter

iProX dataset URI