⮝ Full datasets listing

PXD013373

PXD013373 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTpo1‐mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response
DescriptionCells counteract oxidative stress by altering metabolism, cell cycle and gene expression. However, the mechanisms that coordinate these adaptations are only marginally understood. Here we provide evidence that timing of these responses in yeast requires export of the polyamines spermidine and spermine. We show that during hydrogen peroxide (H2O2) exposure, the polyamine transporter Tpo1 controls spermidine and spermine concentrations and mediates induction of antioxidant proteins, including Hsp70, Hsp90, Hsp104 and Sod1. Moreover, Tpo1 determines a cell cycle delay during adaptation to increased oxidant levels, and affects H2O2 tolerance. Thus, central components of the stress response are timed through Tpo1‐controlled polyamine export.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_03:58:48.163.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJakob Vowinckel
SpeciesList scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationListNo PTMs are included in the dataset
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-04-04 04:18:33ID requested
12019-06-10 08:54:17announced
22019-08-16 00:08:53announcedUpdated publication reference for PubMed record(s): 24136413, 31367038.
32024-10-22 03:59:04announced2024-10-22: Updated project metadata.
Publication List
Olin-Sandoval V, Yu JSL, Miller-Fleming L, Alam MT, Kamrad S, Correia-Melo C, Haas R, Segal J, Pe, ñ, a Navarro DA, Herrera-Dominguez L, M, é, ndez-Lucio O, Vowinckel J, M, ü, lleder M, Ralser M, Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism. Nature, 572(7768):249-253(2019) [pubmed]
10.1038/embor.2013.165;
10.1038/s41586-019-1442-6;
Kr, ü, ger A, Vowinckel J, M, ü, lleder M, Grote P, Capuano F, Bluemlein K, Ralser M, Tpo1-mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response. EMBO Rep, 14(12):1113-9(2013) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: Yeast
Contact List
Markus Ralser
contact affiliationEinstein Professor of Biochemistry Head, Institute of Biochemistry, Charité University Medicine, Berlin
contact emailralser359@gmail.com
lab head
Jakob Vowinckel
contact affiliationBiognosys AG
contact emailjakob.vowinckel@biognosys.com
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/06/PXD013373
PRIDE project URI
Repository Record List
[ + ]