PXD013373 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Tpo1‐mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response |
Description | Cells counteract oxidative stress by altering metabolism, cell cycle and gene expression. However, the mechanisms that coordinate these adaptations are only marginally understood. Here we provide evidence that timing of these responses in yeast requires export of the polyamines spermidine and spermine. We show that during hydrogen peroxide (H2O2) exposure, the polyamine transporter Tpo1 controls spermidine and spermine concentrations and mediates induction of antioxidant proteins, including Hsp70, Hsp90, Hsp104 and Sod1. Moreover, Tpo1 determines a cell cycle delay during adaptation to increased oxidant levels, and affects H2O2 tolerance. Thus, central components of the stress response are timed through Tpo1‐controlled polyamine export. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_03:58:48.163.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jakob Vowinckel |
SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; |
ModificationList | No PTMs are included in the dataset |
Instrument | TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-04-04 04:18:33 | ID requested | |
1 | 2019-06-10 08:54:17 | announced | |
2 | 2019-08-16 00:08:53 | announced | Updated publication reference for PubMed record(s): 24136413, 31367038. |
⏵ 3 | 2024-10-22 03:59:04 | announced | 2024-10-22: Updated project metadata. |
Publication List
Olin-Sandoval V, Yu JSL, Miller-Fleming L, Alam MT, Kamrad S, Correia-Melo C, Haas R, Segal J, Pe, ñ, a Navarro DA, Herrera-Dominguez L, M, é, ndez-Lucio O, Vowinckel J, M, ü, lleder M, Ralser M, Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism. Nature, 572(7768):249-253(2019) [pubmed] |
10.1038/embor.2013.165; |
10.1038/s41586-019-1442-6; |
Kr, ü, ger A, Vowinckel J, M, ü, lleder M, Grote P, Capuano F, Bluemlein K, Ralser M, Tpo1-mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response. EMBO Rep, 14(12):1113-9(2013) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Yeast |
Contact List
Markus Ralser |
contact affiliation | Einstein Professor of Biochemistry Head, Institute of Biochemistry, Charité University Medicine, Berlin |
contact email | ralser359@gmail.com |
lab head | |
Jakob Vowinckel |
contact affiliation | Biognosys AG |
contact email | jakob.vowinckel@biognosys.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013373
- Label: PRIDE project
- Name: Tpo1‐mediated spermine and spermidine export controls cell cycle delay and times antioxidant protein expression during the oxidative stress response