PXD013362

PXD013362 is an original dataset announced via ProteomeXchange.

Title	PACAP and other neuropeptide targets link chronic migraine and opioid-induced hyperalgesia in mouse models
Description	Understanding the precise molecular mechanisms behind chronic pain disorders such as migraine and opioid induced hyperalgesia (OIH) has been a long-standing goal met with limited success. Neuropeptides, which play a vital role in several physiological processes are also hypothesized to be involved in mediating these pain mechanisms. Here we show that change in levels of several neuropeptides and neuropeptide-precursor proteins (prohormones) correlate with migraine and OIH in mice. We also identified common prohormones that are significantly changed in both migraine and OIH. These results suggest that neuropeptides have an important role in these chronic pain disorders and might be key towards unlocking their mechanisms. This knowledge could eventually be utilized in developing an effective cure for these disorders.
HostingRepository	PRIDE
AnnounceDate	2019-11-06
AnnouncementXML	Submission_2019-11-06_06:39:03.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD013362
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Krishna Anapindi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Phospho; Amidated; Glu->pyro-Glu; Oxidation; Acetyl; Dehydro; Gln->pyro-Glu
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-03 06:58:54	ID requested
⏵ 1	2019-11-06 06:39:05	announced

Anapindi KDB, Yang N, Romanova EV, Rubakhin SS, Tipton A, Dripps I, Sheets Z, Sweedler JV, Pradhan AA, PACAP and Other Neuropeptide Targets Link Chronic Migraine and Opioid-induced Hyperalgesia in Mouse Models. Mol Cell Proteomics, 18(12):2447-2458(2019) [pubmed]

submitter keyword: LC-MS, label-free, peptidomics

Jonathan V. Sweedler
contact affiliation	Department of Chemistry, University of Illinois at Urbana-Champaign, IL, 61801
contact email	jseedle@illinois.edu
lab head
Krishna Anapindi
contact affiliation	University of Illinois at Urbana Champaign
contact email	krishna.anapindi@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD013362
     1. Label: PRIDE project
     2. Name: PACAP and other neuropeptide targets link chronic migraine and opioid-induced hyperalgesia in mouse models