PXD013349

PXD013349 is an original dataset announced via ProteomeXchange.

Title	ETS transcription factor ELF5 modulates estrogen action in breast cancer via participation in FOXA1-ER driven transcription
Description	The ETS transcription factor ELF5 drives mammary alveolar development in preparation for lactation by forcing differentiation within the progenitor cell population. In luminal A breast cancer, early disease progression is predicted by high levels of ELF5, and in preclinical models elevated ELF5 is associated with its two key features, the acquisition of resistance to endocrine therapy and increased metastasis. Here we demonstrate using chromatin immunoprecipitation sequencing that ELF5 binding overlaps with FOXA1 and ER at enhancers and promoters, and when elevated causes FOXA1 and ER to bind to new regions of the genome involved in resistance to endocrine therapy.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:05:20.877.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christoph Krisp
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos; TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2019-04-03 00:54:48	ID requested
1	2020-05-26 14:16:22	announced
⏵ 2	2024-10-22 05:05:24	announced	2024-10-22: Updated project metadata.

Piggin CL, Roden DL, Law AMK, Molloy MP, Krisp C, Swarbrick A, Naylor MJ, Kalyuga M, Kaplan W, Oakes SR, Gallego-Ortega D, Clark SJ, Carroll JS, Bartonicek N, Ormandy CJ, ELF5 modulates the estrogen receptor cistrome in breast cancer. PLoS Genet, 16(1):e1008531(2020) [pubmed]

10.1371/journal.pgen.1008531;

curator keyword: Biomedical

submitter keyword: Human, Breast Cancer, RIME, estrogen activation

Christopher Ormandy
contact affiliation	1 Garvan Institute of Medical Research and The Kinghorn Cancer Centre, 384 Victoria Street Darlinghurst Sydney, NSW, 2010, Australia. 2 St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Australia.
contact email	c.ormandy@garvan.org.au
lab head
Christoph Krisp
contact affiliation	University Medical Center Hamburg-Eppendorf Institute of Clinical Chemistry and Laboratory Medicine Mass Spectrometric Proteomics
contact email	c.krisp@uke.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD013349

PRIDE project URI

• PRIDE
  1. PXD013349
     1. Label: PRIDE project
     2. Name: ETS transcription factor ELF5 modulates estrogen action in breast cancer via participation in FOXA1-ER driven transcription