PXD013349 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | ETS transcription factor ELF5 modulates estrogen action in breast cancer via participation in FOXA1-ER driven transcription |
Description | The ETS transcription factor ELF5 drives mammary alveolar development in preparation for lactation by forcing differentiation within the progenitor cell population. In luminal A breast cancer, early disease progression is predicted by high levels of ELF5, and in preclinical models elevated ELF5 is associated with its two key features, the acquisition of resistance to endocrine therapy and increased metastasis. Here we demonstrate using chromatin immunoprecipitation sequencing that ELF5 binding overlaps with FOXA1 and ER at enhancers and promoters, and when elevated causes FOXA1 and ER to bind to new regions of the genome involved in resistance to endocrine therapy. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:05:20.877.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Christoph Krisp |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Velos; TripleTOF 5600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-04-03 00:54:48 | ID requested | |
1 | 2020-05-26 14:16:22 | announced | |
⏵ 2 | 2024-10-22 05:05:24 | announced | 2024-10-22: Updated project metadata. |
Publication List
Piggin CL, Roden DL, Law AMK, Molloy MP, Krisp C, Swarbrick A, Naylor MJ, Kalyuga M, Kaplan W, Oakes SR, Gallego-Ortega D, Clark SJ, Carroll JS, Bartonicek N, Ormandy CJ, ELF5 modulates the estrogen receptor cistrome in breast cancer. PLoS Genet, 16(1):e1008531(2020) [pubmed] |
10.1371/journal.pgen.1008531; |
Keyword List
curator keyword: Biomedical |
submitter keyword: Human, Breast Cancer, RIME, estrogen activation |
Contact List
Christopher Ormandy |
contact affiliation | 1 Garvan Institute of Medical Research and The Kinghorn Cancer Centre, 384 Victoria Street Darlinghurst Sydney, NSW, 2010, Australia. 2 St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Australia. |
contact email | c.ormandy@garvan.org.au |
lab head | |
Christoph Krisp |
contact affiliation | University Medical Center Hamburg-Eppendorf Institute of Clinical Chemistry and Laboratory Medicine Mass Spectrometric Proteomics |
contact email | c.krisp@uke.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013349
- Label: PRIDE project
- Name: ETS transcription factor ELF5 modulates estrogen action in breast cancer via participation in FOXA1-ER driven transcription