PXD013269

PXD013269 is an original dataset announced via ProteomeXchange.

Title	Screening of serum biomarkers of preeclampsia by proteomics combination with bioinformatics
Description	Objective: To screen for novel predictive serum markers of preeclampsia (PE). Method: Blood samples were collected from 7 women with PE and 5 with healthy pregnancies. Serum proteins were identified using ITRAQ technology combined with liquid chromatography mass spectrometry analysis. The differential expressed proteins in the PE samples were identified using the SwissProt database, and functionally annotated by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses Results: We identified 121 differential expressed proteins, of which 76 were up-regulated and 45 were down-regulated, and 14 were differential expressed by more than 2-folds. The top GO terms for Cellular Components (CC) were high-density lipoprotein particles and plasma lipoprotein particles, defense response for Biological Processes (BP), and glycosaminoglycan binding, heparin binding and sulfur compound for Molecular functions (MF). The pathway hsa04979 for Cholesterol metabolism was significantly enriched among the upregulated proteins, while structural domain was enriched in immunoglobulin subtype 2. Conclusion: PE pathogenesis is related to lipid metabolism and inflammation, and proteins related to these pathways are potential early diagnostic markers for PE.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:04:18.995.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	xiaomei li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-27 04:32:24	ID requested
1	2019-10-15 09:25:34	announced
⏵ 2	2024-10-22 04:04:27	announced	2024-10-22: Updated project metadata.

Ling Y, Su J, Lin J, Wang S, Screening of serum biomarkers of preeclampsia by proteomics combination with bioinformatics. Hypertens Pregnancy, 38(3):184-192(2019) [pubmed]

10.1080/10641955.2019.1640246;

submitter keyword: ITRAQ, Blood,Proteomics

Sumei Wang
contact affiliation	Department of obstetric, The First Affiliated Hospital of Guangxi Medical University.
contact email	187176076@qq.com
lab head
xiaomei li
contact affiliation	PTM Biolabs lnc.
contact email	xiaomei_li@ptm-biolab.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD013269
     1. Label: PRIDE project
     2. Name: Screening of serum biomarkers of preeclampsia by proteomics combination with bioinformatics