PXD013266

PXD013266 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of differentially expressed proteins in two Trypanosoma vivax strains with different patterns of virulence and pathogenicity in sheep.
Description	Cattle trypanosomosis caused by Trypanosoma vivax is a widely distributed disease in Africa and Latin America. It causes significant losses in the livestock industry and is characterized by fever, parasitemia, anemia, lethargy, and weight loss. In this study we evaluated the virulence (capacity to multiply inside the host) and pathogenicity (ability to produce disease and/or mortality) patterns of two T. vivax strains (TvMT1 and TvLIEM176) in experimentally-infected sheep and determined the proteins differentially expressed in the proteomes of these two strains. There was a marked difference in the virulence and pathogenicity between both T. vivax strains: TvLIEM176 showed high virulence and moderate pathogenicity, whereas TvMT1 showed low virulence and high pathogenicity. In the proteomic analysis, we identified a total of 29 proteins associated with the different biological behaviour, of which 14 exhibited significant differences in their expression level between the two strains. The proteins evidenced in this study are considered potential virulence and pathogenicity biomarkers in T. vivax infections, and deserve further investigations to precise their functional role in the host-parasite interactions.
HostingRepository	PRIDE
AnnounceDate	2019-10-17
AnnouncementXML	Submission_2019-10-17_10:42:18.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Oana Vigy
SpeciesList	scientific name: Trypanosoma; NCBI TaxID: 5690;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap XL

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-27 04:16:59	ID requested
⏵ 1	2019-10-17 10:42:19	announced

Dataset with its publication pending

submitter keyword: Trypanosoma vivax

virulence

pathogenicity

proteomics

biomarkers

Roger A. Ramirez Barrios
contact affiliation	1. Laboratorio de Enfermedades Parasitarias, Facultad de Ciencias Veterinarias, Universidad del Zulia, Maracaibo, Venezuela 2. Department of Biomedical Sciences, School of Medicine, University of Minnesota Duluth. 1035 University Drive, Duluth, MN, 55812 USA
contact email	rramirez@d.umn.edu
lab head
Oana Vigy
contact affiliation	FPP CNRS
contact email	oana.vigy@fpp.cnrs.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/10/PXD013266

PRIDE project URI

• PRIDE
  1. PXD013266
     1. Label: PRIDE project
     2. Name: Proteomic analysis of differentially expressed proteins in two Trypanosoma vivax strains with different patterns of virulence and pathogenicity in sheep.