PXD013260

PXD013260 is an original dataset announced via ProteomeXchange.

Title	Label free mass spectrometry quantification of Akt interacting proteins in insulin stimulated cardiomyocytes from Metabolic Syndrome Rats.
Description	In the present work, we used a label-free mass spectrometry approach to identify changes in the abundance of Akt-interacting proteins in cardiomyocytes of MetS rats. Using this strategy, we were able to identify specific proteins with evident dissimilarities in their abundance within the Akt complex. Our data provide for the first time proteomic support to the documented impairment in energy metabolism and insulin signaling in the heart as a consequence of the MetS condition.
HostingRepository	PRIDE
AnnounceDate	2020-02-06
AnnouncementXML	Submission_2020-02-06_04:59:26.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jesus Alberto Olivares
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	amidated residue; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-27 02:43:57	ID requested
⏵ 1	2020-02-06 04:59:30	announced

Landa-Galvan HV, Rios-Castro E, Romero-Garcia T, Rueda A, Olivares-Reyes JA, Metabolic syndrome diminishes insulin-induced Akt activation and causes a redistribution of Akt-interacting proteins in cardiomyocytes. PLoS One, 15(1):e0228115(2020) [pubmed]

curator keyword: Biomedical

submitter keyword: Akt, cardiomyocytes, insulin resistance, label-free mass spectrometry, metabolic syndrome.

Jesús A. Olivares Reyes
contact affiliation	Department of Biochemestry, Cinvestav-IPN, Mexico City, Mexico.
contact email	jolivare@cinvestav.mx
lab head
Jesus Alberto Olivares
contact affiliation	CINVESTAV IPN
contact email	jolivare@cinvestav.mx
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/02/PXD013260

PRIDE project URI

• PRIDE
  1. PXD013260
     1. Label: PRIDE project
     2. Name: Label free mass spectrometry quantification of Akt interacting proteins in insulin stimulated cardiomyocytes from Metabolic Syndrome Rats.