PXD013259

PXD013259 is an original dataset announced via ProteomeXchange.

Title	ISG15 blocks CoxsackieB virus infection and pathology by metabolic and antiviral reprogramming
Description	ISG15 is a ubiquitin-like modifier strongly upregulated in the type I interferon response. It exerts an antiviral function in the host defense against a wide variety of viruses. Recently, we observed that ISG15 expression restricts coxsackievirusB3 (CV) infection both in vitro and in vivo. ISG15-dependent protection against CV infection is concordant with a robust increase of ISGylated proteins in the liver of infected mice. In this study, we examined the role of ISG15 in the regulation of liver proteins at multiple stages of CV infection. To do so, we used shotgun proteomics to quantify the expression levels of the proteins from the liver tissues of wild-type and ISG15-/- mice non-infected and at day 3 and 8 of CV-infection. Our data revealed minor effects of ISG15 on the expression levels of proteins involved in the innate immune response to CV infection. In contrast, ISG15 mediates the regulation of proteins required for liver metabolic processes throughout the course of CV infection. In addition to its direct antiviral properties, our data suggest a critical role for ISG15 in rewiring liver metabolism during CV infection.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:04:07.024.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fabien Thery
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Coxsackievirus; NCBI TaxID: NCBITaxon:12066;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-27 02:42:42	ID requested
1	2019-12-09 05:03:57	announced
⏵ 2	2024-10-22 04:04:07	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: shotgun proteomics,Mouse, coxsackievirus, infection, Liver

Francis Impens
contact affiliation	Center for Medical Biotechnology, VIB, 9000 Ghent, Belgium. Department for Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium. VIB Proteomics Core, VIB, 9000 Ghent, Belgium.
contact email	francis.impens@vib-ugent.be
lab head
Fabien Thery
contact affiliation	VIB-UGent
contact email	fabien.thery91@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD013259
     1. Label: PRIDE project
     2. Name: ISG15 blocks CoxsackieB virus infection and pathology by metabolic and antiviral reprogramming