PXD013247 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | PI31 modulates the quantity of MHC class I loaded peptides in DCs |
| Description | We used siRNAs to knockdown PI31 in primary DCs, followed by capturing HLA class I complexes using W6/32-conjugated immunoresin. Acid treatment abolished noncovalent interactions among the complex components. Using reverse-phase HPLC, we separated eluted peptides from the α-chain and β2-microglobulin of the HLA complexes and analysed eluted peptide fractions by LC-MS/MS. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-28 |
| AnnouncementXML | Submission_2026-05-28_08:51:04.940.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD013247 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Nicola Ternette |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2019-03-26 08:06:36 | ID requested | |
| ⏵ 1 | 2026-05-28 08:51:06 | announced | |
Publication List
| 10.3389/fimmu.2019.00958; |
| 10.6019/PXD013247; |
| Corridoni D, Shiraishi S, Chapman T, Steevels T, Muraro D, Th, é, z, é, nas ML, Prota G, Chen JL, Gileadi U, Ternette N, Cerundolo V, Simmons A, NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses. Front Immunol, 10():958(2019) [pubmed] |
Keyword List
| ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project |
| curator keyword: Biomedical |
| submitter keyword: PI31, Proteasome, Antigen Presentation, MHC class I |
Contact List
| Nicola Ternette |
|---|
| contact affiliation | University of Oxford |
| contact email | nicola.ternette@ndm.ox.ac.uk |
| lab head | |
| Nicola Ternette |
|---|
| contact affiliation | University of Oxford |
| contact email | nicola.ternette@ndm.ox.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD013247
- Label: PRIDE project
- Name: PI31 modulates the quantity of MHC class I loaded peptides in DCs
