PXD013242

PXD013242 is an original dataset announced via ProteomeXchange.

Title	Profiling of ADAM12S regulated proteins in H1688 cells
Description	In this project, we used SILAC quantitative proteomics to identify proteins that are differentially regulated by the short secreted form of A Disintegrin And Metalloproteinase 12, ADAM12S, in a small cell lung cancer cell line H1688. The aim of this study is to discover the proteins that are responsible for the cell proliferation, migration, and invasion and then to elucidate the molecular mechanism by which ADAM12S promotes these processes in small cell lung cancer cells.
HostingRepository	PRIDE
AnnounceDate	2021-02-16
AnnouncementXML	Submission_2021-02-16_00:36:25.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dan Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	13C(6) 15N(2) Silac label; monohydroxylated residue; 13C(6) 15N(4) Silac label; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-26 07:29:55	ID requested
⏵ 1	2021-02-16 00:36:25	announced

Duan Q, Li D, Xiong L, Chang Z, Xu G, SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1. J Proteome Res, 18(7):2903-2914(2019) [pubmed]

submitter keyword: Human, H1688, ADAM12S, LC-MS/MS, SILAC quantification, OrbiTrap Elite

Guoqiang Xu
contact affiliation	Collage of pharmaceutical science,Soochow University,Jiangsu Province,China
contact email	gux2002@suda.edu.cn
lab head
Dan Li
contact affiliation	Soochow University
contact email	445220956@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/02/PXD013242

PRIDE project URI

• PRIDE
  1. PXD013242
     1. Label: PRIDE project
     2. Name: Profiling of ADAM12S regulated proteins in H1688 cells