PXD013157

PXD013157 is an original dataset announced via ProteomeXchange.

Title	A systems chemoproteomic analysis of acyl-CoA signaling networks
Description	Acyl-CoAs are essential for life. These metabolites serve as fundamental cellular building blocks in the biosynthesis of lipids, intermediates in energy production via the TCA cycle, and essential precursors for reversible protein acetylation. Each of these roles are dependent on acyl-CoA/protein interactions, physical contacts that can regulate protein function via a variety of mechanisms. We utilized systems-level analyses to characterize novel protein networks that interact with metabolic acyl-CoAs, and evaluate the potential of these interactions to facilitate enzyme activity or non-enzymatic acylation. Our studies provide a roadmap for integrating chemoproteomic data with systems biology analysis, and establish a novel resource for understanding the diverse signaling roles of acyl-CoAs in biology and disease.
HostingRepository	PRIDE
AnnounceDate	2019-11-21
AnnouncementXML	Submission_2019-11-21_03:57:44.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD013157
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Michaella Levy
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-20 04:20:11	ID requested
⏵ 1	2019-11-21 03:57:45	announced

Dataset with its publication pending

submitter keyword: Acyl-CoA, proteomics, MudPIT, acetyltransferase

Laurence Florens
contact affiliation	Stowers Institute for Medical Research
contact email	laf@stowers.org
lab head
Michaella Levy
contact affiliation	Stowers Institute for Medical Research
contact email	mly@stowers.org
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD013157
     1. Label: PRIDE project
     2. Name: A systems chemoproteomic analysis of acyl-CoA signaling networks