Updated FTP location. The current work involves the quantitative analysis of total proteome of M. tuberculosis H37Rv depleted with the expression of different clp genes viz., clpP2, clpX and clpC1, respectively, by iTRAQ. Silencing of these genes was performed by CRISPRi approach by co-expression of specific guide sequence and dCas9 under the regulation of ATc-inducible promoter.