PXD013150

PXD013150 is an original dataset announced via ProteomeXchange.

Title	Label-free proteomics reveal that plasma protein expression differs between colorectal cancer patients according to tumor stage, location, patient survival, preoperative radiotherapy status, or gender.
Description	Colorectal cancer (CRC) is the third most common cancer worldwide and is a heterogeneous disease, with differences between cancer in the right colon, left colon, and rectum. In this study, plasma samples from CRC patients with varying stage (II or III), primary tumor location (right colon, left colon, or rectum) and survival (survived or died due to CRC) were studied with quantitative label-free proteomics using ultra-definition MSE. Patients were also divided into subgroups based on preoperative radiotherapy status and gender. Further analysis subsequently identified multiple plasma proteins whose expression differed depending on tumor stage, location, patient survival, preoperative radiotherapy status, or gender.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:01:05.274.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD013150
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Sakari Joenväärä
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Ammonia-loss; Dehydrated; Oxidation; Carbamidomethyl
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-19 09:59:33	ID requested
1	2019-08-22 08:51:33	announced
2	2019-12-13 04:22:40	announced	2019-12-13: Updated publication reference for DOI(s): 10.1186/s41231-019-0044-5.
3	2020-04-21 01:26:04	announced	2019-12-13: Updated publication reference for DOI(s): 10.1186/s41231-019-0044-5. 2020-04-21: Updated publication reference for PubMed record(s): 32294655. 2020-04-21: Updated publication reference for DOI(s): 10.1186/s41231-019-0044-5.
⏵ 4	2023-11-14 09:01:06	announced	2023-11-14: Updated project metadata.

Holm M, Joenv, ä, ä, r, ä S, Saraswat M, Tohmola T, Ristim, ä, ki A, Renkonen R, Haglund C, Preoperative Radiotherapy Leads to Significant Differences in the Plasma Protein Profile of Rectal Cancer Patients. Oncology, 98(7):493-500(2020) [pubmed]

10.6019/PXD013150;

submitter keyword: proteomics,Human colorectal cancer, UDMSE, Label-free quantitation

Risto Renkonen
contact affiliation	- Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland - HUSLAB, Helsinki University Hospital, Helsinki, Finland
contact email	risto.renkonen@helsinki.fi
lab head
Sakari Joenväärä
contact affiliation	Helsinki University
contact email	sakari.joenvaara@helsinki.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD013150

PRIDE project URI

• PRIDE
  1. PXD013150
     1. Label: PRIDE project
     2. Name: Label-free proteomics reveal that plasma protein expression differs between colorectal cancer patients according to tumor stage, location, patient survival, preoperative radiotherapy status, or gender.