PXD013134

PXD013134 is an original dataset announced via ProteomeXchange.

Title	ProTargetMiner: A proteome library of anticancer molecules for functional discovery
Description	ProTargetMiner is the first publicly available expandable proteome signature library of anticancer molecules in cancer cell lines. The compounds cluster into groups by their proteomic signatures based on their targets and mechanisms. These can be deconvoluted by orthogonal partial least square (OPLS) modeling. Using 9 molecules representing most diverse action mechanisms, deep proteome datasets were built for 3 major cancer cell lines MCF-7, RKO and A549. Combining the data from the three cell lines identified common targets and mechanisms, while also highlighting important cell-specific differences. The database can be easily extended and merged with new compound signatures. We expect ProTargetMiner to serve as a valuable chemical proteomics resource catering primarily to the cancer research community, and become a popular tool in drug discovery. This submission includes the deep proteomics datasets in MCF-7 and RKO cell lines.
HostingRepository	PRIDE
AnnounceDate	2019-11-01
AnnouncementXML	Submission_2020-01-13_05:27:51.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Amir Ata Saei
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-19 02:34:09	ID requested
1	2019-11-01 06:41:36	announced
⏵ 2	2020-01-13 05:27:52	announced	2020-01-13: Updated publication reference for PubMed record(s): 31844049.

Saei AA, Beusch CM, Chernobrovkin A, Sabatier P, Zhang B, Tokat Ü G, Stergiou E, Gaetani M, V, é, gv, á, ri Á, Zubarev RA, ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery. Nat Commun, 10(1):5715(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: MCF-7, RKO, cancer, chemotherapeutic, compound, database, drug, expression, mass spectrometry, proteomics, resource

Roman Zubarev
contact affiliation	Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
contact email	Roman.zubarev@ki.se
lab head
Amir Ata Saei
contact affiliation	Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
contact email	amirata.saei.dibavar@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD013134

PRIDE project URI

• PRIDE
  1. PXD013134
     1. Label: PRIDE project
     2. Name: ProTargetMiner: A proteome library of anticancer molecules for functional discovery