PXD013129

PXD013129 is an original dataset announced via ProteomeXchange.

Title	VDAC2 ligands selectively and potently block BAK-mediated apoptosis to allow long-term clonogenic cell survival
Description	This study aimed to characterise the protein that a novel compound binds to, thus promoting its ability to inhibit BAK apoptotic activity.
HostingRepository	PRIDE
AnnounceDate	2019-10-11
AnnouncementXML	Submission_2019-10-11_00:29:58.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jarrod Sandow
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-18 08:36:45	ID requested
⏵ 1	2019-10-11 00:29:59	announced

van Delft MF, Chappaz S, Khakham Y, Bui CT, Debrincat MA, Lowes KN, Brouwer JM, Grohmann C, Sharp PP, Dagley LF, Li L, McArthur K, Luo MX, Chin HS, Fairlie WD, Lee EF, Segal D, Duflocq S, Lessene R, Bernard S, Peilleron L, Nguyen T, Miles C, Wan SS, Lane RM, Wardak A, Lackovic K, Colman PM, Sandow JJ, Webb AI, Czabotar PE, Dewson G, Watson KG, Huang DCS, Lessene G, Kile BT, A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nat Chem Biol, 15(11):1057-1066(2019) [pubmed]

submitter keyword: Compound target ID

Andrew Webb
contact affiliation	Advanced Technology Walter & ELiza Hall Institute
contact email	webb@wehi.edu.au
lab head
Jarrod Sandow
contact affiliation	WEHI
contact email	sandow@wehi.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/10/PXD013129

PRIDE project URI

• PRIDE
  1. PXD013129
     1. Label: PRIDE project
     2. Name: VDAC2 ligands selectively and potently block BAK-mediated apoptosis to allow long-term clonogenic cell survival