PXD013122

PXD013122 is an original dataset announced via ProteomeXchange.

Title	Tyrosine-protein phophatase non-receptor type 2 (PTPN2) deficiency increases short-lived effector T-cell survival and augments autonomous proliferation of T-cells
Description	Whole proteome and phosphoproteome analysis of T-cells isolated from PTPN2 wild-type and knock-out micestrongly linked amplified T cell numbers to increased proliferation mediated by transcriptional activation of the signal transducer and activator of transcription (STAT) protein family. Subsequent analysis confirmed improved proliferation and survival but not an increase in initial engraftment to be the cause of higher T cell numbers upon adoptive transfer.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:10:01.145.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jana Zecha
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-18 07:41:43	ID requested
1	2020-07-29 04:07:59	announced
2	2020-08-02 22:30:38	announced	2020-08-03: Updated publication reference for PubMed record(s): 32726622.
⏵ 3	2024-10-22 05:10:02	announced	2024-10-22: Updated project metadata.

Flosbach M, Oberle SG, Scherer S, Zecha J, von Hoesslin M, Wiede F, Chennupati V, Cullen JG, List M, Pauling JK, Baumbach J, Kuster B, Tiganis T, Zehn D, PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells. Cell Rep, 32(4):107957(2020) [pubmed]

10.1016/j.celrep.2020.107957;

submitter keyword: T-cells, MS3, TMT, PTPN2, phosphoproteomics

Bernhard Kuster
contact affiliation	Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany
contact email	kuster@tum.de
lab head
Jana Zecha
contact affiliation	Technical University of Munich, Freising, Germany
contact email	jana.zecha@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/07/PXD013122

PRIDE project URI

• PRIDE
  1. PXD013122
     1. Label: PRIDE project
     2. Name: Tyrosine-protein phophatase non-receptor type 2 (PTPN2) deficiency increases short-lived effector T-cell survival and augments autonomous proliferation of T-cells