PXD013095

PXD013095 is an original dataset announced via ProteomeXchange.

Title	Role of bcatenin in hepatocellular carcinoma
Description	Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. β-catenin is widely thought to be a major oncogene in HCC based on the frequency of mutations associated with aberrant Wnt signaling in HCC patients. Challenging this model, our data reveal that β-catenin nuclear accumulation is restricted to the late stage of the disease. Until then, β-catenin is primarily located at the plasma membrane in complex with multiple cadherin family members where it drives tumor cell survival by enhancing the signaling of growth factor receptors such as EGFR. Therefore, our study reveals the evolving nature of β-catenin in HCC to establish it as a compound tumor promoter during the progression of the disease.
HostingRepository	PRIDE
AnnounceDate	2019-03-29
AnnouncementXML	Submission_2019-03-29_12:06:57.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD013095
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Katharina Hayer
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Oxidation; Carbamidomethyl
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-14 06:44:11	ID requested
⏵ 1	2019-03-29 12:06:58	announced

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: bcatenin, liver cancer

Patrick Viatour
contact affiliation	Center for Childhood Cancer Research Children's Hospital of Philadelphia Department of Pathology and Laboratory Medicine University of Pennsylvania
contact email	pviatour@pennmedicine.upenn.edu
lab head
Katharina Hayer
contact affiliation	CHOP
contact email	hayerk@email.chop.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD013095

PRIDE project URI

• PRIDE
  1. PXD013095
     1. Label: PRIDE project
     2. Name: Role of bcatenin in hepatocellular carcinoma