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PXD013072

PXD013072 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic Analysis of FSCN1-Interacting Proteins in LSCC cells
DescriptionFascin actin-bundling protein 1 (FSCN1) is an evolutionarily conserved actin-bundling protein that plays a critical role in cell migration, motility, adhesion and cellular interactions. Although multiple clinical studies have implicated the expression of FSCN1 in laryngeal squamous cell carcinoma (LSCC) progression, the precise mechanism of FSCN1 in the process has not been clearly elucidated. To define FSCN1 function, we characterized FSCN1-interacting proteins in LSCC cells by immunoprecipitation followed by LC-MS/MS. After data filtering, 119 proteins with expression in both the Hep-2 and TU-177 cell samples were identified as FSCN1-interacting partners. With in-depth bioinformatics analysis, we linked FSCN1 to critical cellular processes including cell adhesion, glycolysis/gluconeogenesis, regulation of protein ubiquitination, ribosomal RNA processing and small molecule metabolism. We discuss the interactions between FSCN1 and some of the newly validated partners. The identification of these potential partners of FSCN1 expands our knowledge of the FSCN1 interactome and provides a valuable resource for understanding the functions of this protein in LSCC progression.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:10:45.876.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLiu Hongliang
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-03-13 03:45:54ID requested
12019-09-09 09:28:06announced
22024-10-22 04:10:54announced2024-10-22: Updated project metadata.
Publication List
10.1002/iub.2121;
Liu H, Cui J, Zhang Y, Niu M, Xue X, Yin H, Tang Y, Dai L, Dai F, Guo Y, Wu Y, Gao W, Mass spectrometry-based proteomic analysis of FSCN1-interacting proteins in laryngeal squamous cell carcinoma cells. IUBMB Life, 71(11):1771-1784(2019) [pubmed]
Keyword List
submitter keyword: LSCC, LS-MS/MS,FSCN1, interactomics, immunoprecipitation
Contact List
Wang Binquan
contact affiliationShanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Shanxi Medical University,China
contact emailwbq_xy@sxent.org
lab head
Liu Hongliang
contact affiliationShanxi Medical University
contact emailliuhl2018@sxent.org
dataset submitter
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Dataset FTP location
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PRIDE project URI
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