PXD013020

PXD013020 is an original dataset announced via ProteomeXchange.

Title	Isoproterenol-induced cardiac hypertrophy trigger proteome remodeling of mouse cardiomyocytes
Description	Cardiac hypertrophy consists in the enlargement of cardiomyocytes and alteration of the extracellular matrix organization in response to physiological or pathological stress. In pathological hypertrophy ocuurs myocardial damage, loss of cardiomyocytes, fibrosis, inflammation, sarcomere disorganization and metabolic impairment, leading to cardiac dysfunction.The rodent model treated with isoproterenol induces cardiac hypertrophy due the constant activation of β-adrenergic receptors. We conducted a quantitative label-free proteomic analysis of cardiomyocytes isolated from hearts of mice treated or not with isoproterenol to better understand the molecular bases of cellular response due to isoproterenol-induced injury.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:06:15.401.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thiago Verano-Braga
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-08 08:08:41	ID requested
1	2020-05-27 01:31:26	announced
2	2020-08-11 06:01:56	announced	2020-08-11: Updated publication reference for PubMed record(s): 32506788.
⏵ 3	2024-10-22 05:06:18	announced	2024-10-22: Updated project metadata.

10.1002/prca.202000017;

Parreira RC, G, ó, mez-Mendoza DP, de Jesus ICG, Lemos RP, Santos AK, Rezende CP, Figueiredo HCP, Pinto MCX, Kjeldsen F, Guatimosim S, Resende RR, Verano-Braga T, Cardiomyocyte Proteome Remodeling due to Isoproterenol-Induced Cardiac Hypertrophy during the Compensated Phase. Proteomics Clin Appl, 14(4):e2000017(2020) [pubmed]

submitter keyword: hypertrophy, heart, mouse,isoproterenol

Thiago Verano-Braga
contact affiliation	Departamento de Fisiologia e Biofisica, Universidade Federal de Minas Gerais
contact email	tvbraga@icb.ufmg.br
lab head
Thiago Verano-Braga
contact affiliation	Federal University of Minas Gerais
contact email	npf.ufmg@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD013020

PRIDE project URI

• PRIDE
  1. PXD013020
     1. Label: PRIDE project
     2. Name: Isoproterenol-induced cardiac hypertrophy trigger proteome remodeling of mouse cardiomyocytes