PXD012998

PXD012998 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of endometrioid and high-grade serous ovarian tumour samples
Description	Precision medicine approaches in ovarian cancer require the accurate diagnosis of histotypes. In particular, there is a critical need to distinguish endometroid (EC) from high grade serous (HGSC) carcinomas, which differ greatly in outcomes, genetic predisposition and optimal treatment approaches. Herein, we performed label-free quantitative proteomics on freshly frozen tumour tissues to discover biomarkers that may distinguish EC from HGSC, and then used IHC to validate these using a contemporarily classified cohort of EC and HGSC samples.
HostingRepository	PRIDE
AnnounceDate	2019-03-13
AnnouncementXML	Submission_2019-04-18_02:07:38.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dylan Dieters-Castator
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	deamidated residue; iodoacetamide derivatized residue
Instrument	Exactive Plus; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-06 07:12:18	ID requested
1	2019-03-13 16:34:54	announced
⏵ 2	2019-04-18 02:07:39	announced	Updated publication reference for PubMed record(s): 30979743.

Dieters-Castator DZ, Rambau PF, Kelemen LE, Siegers GM, Lajoie GA, Postovit LM, K, ö, bel M, Proteomics-Derived Biomarker Panel Improves Diagnostic Precision to Classify Endometrioid and High-grade Serous Ovarian Carcinoma. Clin Cancer Res, 25(14):4309-4319(2019) [pubmed]

submitter keyword: proteomics, endometrioid ovarian cancer, high grade serous ovarian cancer, biomarker, immunohistochemistry, label-free quantification

Gilles A. Lajoie
contact affiliation	Department of Biochemistry, Siebens Drake Research Institute, Western University
contact email	glajoie@uwo.ca
lab head
Dylan Dieters-Castator
contact affiliation	Western University
contact email	ddieters@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/03/PXD012998

PRIDE project URI

• PRIDE
  1. PXD012998
     1. Label: PRIDE project
     2. Name: Proteomic analysis of endometrioid and high-grade serous ovarian tumour samples