PXD012974

PXD012974 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	comparative proteomic analysis without a label based on the technology of tandem HPLC - MS/MS
Description	The relative differences between post-translational modifications (PTM) of proteins in blood plasma samples of patients with cerebral ischemia (CI) and healthy people were investigated on the basis of the method of comparative proteomic analysis without a label based on the technology of tandem HPLC - MS/MS. For the detection of PTM, we used multiple search MS / MS in the database Mascot installed variable PTM and Progenesis LS-MS software. In the CI plasma, we observed an increase in the share of posttranslation modified peptides. Such PTM proteins as phosphorylation of serine, threonine and tyrosine, acetylation of lysine and N-terminal protein, ubiquitination of lysine and deamidation of glutamine related to clinically significant processes were revealed.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:54:14.991.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ekaterina Ilgisonis
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	ubiquitination signature tetrapeptidyl lysine; phosphorylated residue; acetylated residue; deamidated residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-05 05:58:03	ID requested
1	2019-12-04 01:53:28	announced
⏵ 2	2024-10-22 04:54:23	announced	2024-10-22: Updated project metadata.

Publication List

Kisrieva YS, Petushkova NA, Samenkova NF, Kuznetsova GP, Larina OB, Teryaeva NB, Usachev DY, Zgoda VG, Karuzina II, [Comparative analysis of post-translational modifications in plasma proteome of patients with cerebral ischemia based on HPLC-MS/MS method]. Biomed Khim, 65(3):251-258(2019) [pubmed]
10.18097/pbmc20196503251;

Kisrieva YS, Petushkova NA, Samenkova NF, Kuznetsova GP, Larina OB, Teryaeva NB, Usachev DY, Zgoda VG, Karuzina II, [Comparative analysis of post-translational modifications in plasma proteome of patients with cerebral ischemia based on HPLC-MS/MS method]. Biomed Khim, 65(3):251-258(2019) [pubmed]

10.18097/pbmc20196503251;

Keyword List

ProteomeXchange project tag: Human Proteome Project
submitter keyword: Liquid Chromatography and Mass Spectrometry,post-translational modifications of proteins, cerebral ischemia, blood plasma proteome, Orbitrap

ProteomeXchange project tag: Human Proteome Project

submitter keyword: Liquid Chromatography and Mass Spectrometry,post-translational modifications of proteins, cerebral ischemia, blood plasma proteome, Orbitrap

Contact List

Irina Karuzina
contact affiliation	Institute of Biomedical Chemistry
contact email	juliaks@bk.ru
lab head
Ekaterina Ilgisonis
contact affiliation	IBMC
contact email	ilgisonis.ev@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/12/PXD012974
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/12/PXD012974

PRIDE project URI

Repository Record List

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