PXD012956

PXD012956 is an original dataset announced via ProteomeXchange.

Title	Role of ppiB in burkholderia pseudomallei
Description	Burkholderia pseudomallei is the causative agent of melioidosis a disease endemic in South-East Asia and Northern Australia. The mortality rates in these areas are unacceptably high even with antibiotic treatment, attributed to intrinsic and acquired resistance of B. pseudomallei to antibiotics. With very few options for therapeutics there is an urgent requirement to identify anti-bacterial targets for the development of novel, effective treatments. In this study we examine the role and effect of ppiB on the proteome. Using LFQ analysis we show loss of ppiB has dramatic effect on the Burkholderia pseudomallei proteome.
HostingRepository	PRIDE
AnnounceDate	2019-08-05
AnnouncementXML	Submission_2019-08-05_02:15:42.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nichollas Scott
SpeciesList	scientific name: Burkholderia pseudomallei; NCBI TaxID: 28450;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2019-03-05 01:55:51	ID requested
⏵ 1	2019-08-05 02:15:43	announced

Bzdyl NM, Scott NE, Norville IH, Scott AE, Atkins T, Pang S, Sarovich DS, Coombs G, Inglis TJJ, Kahler CM, Sarkar-Tyson M, Is Essential for Proteome Homeostasis and Virulence in Burkholderia pseudomallei. Infect Immun, 87(10):(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: burkholderia pseudomallei, LFQ, Proteomics

Dr Mitali Sarkar-Tyson
contact affiliation	Marshall Centre for Infectious Diseases Research and Training School of Biomedical Sciences University of Western Australia Perth, WA, Australia
contact email	mitali.sarkar-tyson@uwa.edu.au
lab head
Nichollas Scott
contact affiliation	University of Melbourne
contact email	nichollas.scott@unimelb.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD012956

PRIDE project URI

• PRIDE
  1. PXD012956
     1. Label: PRIDE project
     2. Name: Role of ppiB in burkholderia pseudomallei