PXD012953 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Dasatinib for the treatment of gastric cancer |
Description | Gastric cancer (GC) represents a major health problem, remaining the fifth most common type of cancer and the third leading cause of cancer-related death worldwide with only few targeted therapies available to date. The positive effect of kinase inhibitors on many different types of cancers has prompted the investigation of these compounds also in GC. In a screen of FDA-approved kinase inhibitors, dasatinib was found as a potent inhibitor of gastric cancer cells migration and invasion. In order to identify the kinases involved proteomics analysis was performed identifying SRC kinases, Ephrins and DDR1 as potential molecular targets. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:05:14.359.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Stephanie Wilhelm |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-03-05 00:51:35 | ID requested | |
1 | 2020-05-26 14:01:04 | announced | |
⏵ 2 | 2024-10-22 05:05:16 | announced | 2024-10-22: Updated project metadata. |
Publication List
Montenegro RC, Howarth A, Ceroni A, Fedele V, Farran B, Mesquita FP, Frejno M, Berger BT, Heinzlmeir S, Sailem HZ, Tesch R, Ebner D, Knapp S, Burbano R, Kuster B, M, ü, ller S, Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib. Oncotarget, 11(5):535-549(2020) [pubmed] |
10.18632/oncotarget.27462; |
Keyword List
curator keyword: Biomedical |
submitter keyword: Dasatinib, Src kinases,Gastric cancer, Kinobeads |
Contact List
Bernhard Kuster |
contact affiliation | Chair of Proteomics and Bioanalytics, Technische Universität München, Germany |
contact email | kuster@tum.de |
lab head | |
Stephanie Wilhelm |
contact affiliation | Chair of Proteomics and Bioanalytics, Technische Universität München, Germany |
contact email | stephanie.heinzlmeir@tum.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD012953
- Label: PRIDE project
- Name: Dasatinib for the treatment of gastric cancer