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PXD012953

PXD012953 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDasatinib for the treatment of gastric cancer
DescriptionGastric cancer (GC) represents a major health problem, remaining the fifth most common type of cancer and the third leading cause of cancer-related death worldwide with only few targeted therapies available to date. The positive effect of kinase inhibitors on many different types of cancers has prompted the investigation of these compounds also in GC. In a screen of FDA-approved kinase inhibitors, dasatinib was found as a potent inhibitor of gastric cancer cells migration and invasion. In order to identify the kinases involved proteomics analysis was performed identifying SRC kinases, Ephrins and DDR1 as potential molecular targets.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:05:14.359.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterStephanie Wilhelm
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-03-05 00:51:35ID requested
12020-05-26 14:01:04announced
22024-10-22 05:05:16announced2024-10-22: Updated project metadata.
Publication List
Montenegro RC, Howarth A, Ceroni A, Fedele V, Farran B, Mesquita FP, Frejno M, Berger BT, Heinzlmeir S, Sailem HZ, Tesch R, Ebner D, Knapp S, Burbano R, Kuster B, M, ü, ller S, Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib. Oncotarget, 11(5):535-549(2020) [pubmed]
10.18632/oncotarget.27462;
Keyword List
curator keyword: Biomedical
submitter keyword: Dasatinib, Src kinases,Gastric cancer, Kinobeads
Contact List
Bernhard Kuster
contact affiliationChair of Proteomics and Bioanalytics, Technische Universität München, Germany
contact emailkuster@tum.de
lab head
Stephanie Wilhelm
contact affiliationChair of Proteomics and Bioanalytics, Technische Universität München, Germany
contact emailstephanie.heinzlmeir@tum.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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