PXD012921 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mass spectrometry-based characterization of the virion proteome and phosphoproteome of human cytomegalovirus |
Description | The assembly of human cytomegalovirus (HCMV) virions is an orchestrated process that requires, as an essential prerequisite, the complex crosstalk between viral structural proteins. So far, however, the mechanisms governing the successive steps in the constitution of virion protein complexes remained elusive. Protein phosphorylation is a key regulator determining the sequential changes in conformation, binding, dynamics and stability of proteins in the course of multiprotein assembly. Here, we present new results to complete knowledge on HCMV virion proteome and phosphoproteome. Thus, a novel dataset of viral and cellular proteins contained in HCMV virions has been generated, providing a basis for future analyses of individual phosphorylation steps and sites involved in the orchestrated assembly of HCMV virion-specific multiprotein complexes. |
HostingRepository | PRIDE |
AnnounceDate | 2020-06-05 |
AnnouncementXML | Submission_2020-06-04_23:04:15.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD012921 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Yohann Couté |
SpeciesList | scientific name: Human herpesvirus 5 strain AD169; NCBI TaxID: 10360; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | Phospho; Oxidation; Acetyl; Carbamidomethyl |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-03-01 01:56:39 | ID requested | |
⏵ 1 | 2020-06-04 23:04:15 | announced | |
Publication List
Cout, é Y, Kraut A, Zimmermann C, B, ü, scher N, Hesse AM, Bruley C, De Andrea M, Wangen C, Hahn F, Marschall M, Plachter B, Mass Spectrometry-Based Characterization of the Virion Proteome, Phosphoproteome, and Associated Kinase Activity of Human Cytomegalovirus. Microorganisms, 8(6):(2020) [pubmed] |
Keyword List
submitter keyword: Human cytomegalovirus |
virion composition |
proteins |
phosphorylation |
mass spectrometry-based proteomics |
Contact List
Virginie Brun |
contact affiliation | EDyP |
contact email | virginie.brun@cea.fr |
lab head | |
Yohann Couté |
contact affiliation | EDyP |
contact email | yohann.coute@cea.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD012921 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD012921
- Label: PRIDE project
- Name: Mass spectrometry-based characterization of the virion proteome and phosphoproteome of human cytomegalovirus