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PXD012921

PXD012921 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMass spectrometry-based characterization of the virion proteome and phosphoproteome of human cytomegalovirus
DescriptionThe assembly of human cytomegalovirus (HCMV) virions is an orchestrated process that requires, as an essential prerequisite, the complex crosstalk between viral structural proteins. So far, however, the mechanisms governing the successive steps in the constitution of virion protein complexes remained elusive. Protein phosphorylation is a key regulator determining the sequential changes in conformation, binding, dynamics and stability of proteins in the course of multiprotein assembly. Here, we present new results to complete knowledge on HCMV virion proteome and phosphoproteome. Thus, a novel dataset of viral and cellular proteins contained in HCMV virions has been generated, providing a basis for future analyses of individual phosphorylation steps and sites involved in the orchestrated assembly of HCMV virion-specific multiprotein complexes.
HostingRepositoryPRIDE
AnnounceDate2020-06-05
AnnouncementXMLSubmission_2020-06-04_23:04:15.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD012921
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterYohann Couté
SpeciesList scientific name: Human herpesvirus 5 strain AD169; NCBI TaxID: 10360; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListPhospho; Oxidation; Acetyl; Carbamidomethyl
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-03-01 01:56:39ID requested
12020-06-04 23:04:15announced
Publication List
Cout, é Y, Kraut A, Zimmermann C, B, ü, scher N, Hesse AM, Bruley C, De Andrea M, Wangen C, Hahn F, Marschall M, Plachter B, Mass Spectrometry-Based Characterization of the Virion Proteome, Phosphoproteome, and Associated Kinase Activity of Human Cytomegalovirus. Microorganisms, 8(6):(2020) [pubmed]
Keyword List
submitter keyword: Human cytomegalovirus
virion composition
proteins
phosphorylation
mass spectrometry-based proteomics
Contact List
Virginie Brun
contact affiliationEDyP
contact emailvirginie.brun@cea.fr
lab head
Yohann Couté
contact affiliationEDyP
contact emailyohann.coute@cea.fr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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