PXD012902

PXD012902 is an original dataset announced via ProteomeXchange.

Title	Corneal protome of trangenic TGFBI R124H mouse model
Description	In this study we analysed the proteome of transforming growth factor β-induced protein (TGFBIp) R124H transgenic mouse corneas in an attempt to understand the disease mechanisms leading to the granular corneal dystrophy type 2. The transgenic mouse model was generated by insertion of human TGFBI cDNA with the R124H mutation into the first exon of the mouse TGFBI DNA generating the transgenic TGFBIR124H mouse model We compared the corneal proteome of three wild-type, heterozygous, and homozygous mice of different genders, which were age-matched and analysed the proteolytic processing and relative amount of TGFBIp. No protein deposits were observed in the investigated corneas.
HostingRepository	PRIDE
AnnounceDate	2020-10-20
AnnouncementXML	Submission_2020-10-20_00:09:11.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marie Vestergaard Lukassen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	homoserine lactone; homoserine; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-28 01:14:02	ID requested
⏵ 1	2020-10-20 00:09:12	announced

Lukassen MV, Poulsen ET, Donaghy J, Mogensen EH, Christie KA, Roshanravan H, DeDioniso L, Nesbit MA, Moore T, Enghild JJ, Mouse Model Gives Insight into Phenotype Development of Granular Corneal Dystrophy. Proteomics Clin Appl, 14(6):e1900072(2020) [pubmed]

curator keyword: Biological

submitter keyword: Mouse, cornea, LC-MS/MS

Jan J. Enghild
contact affiliation	Department of Molecular Biology and Genetics, Aarhus University, Denmark
contact email	jje@mbg.au.dk
lab head
Marie Vestergaard Lukassen
contact affiliation	Aarhus University
contact email	mvl@inano.au.dk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/10/PXD012902

PRIDE project URI

• PRIDE
  1. PXD012902
     1. Label: PRIDE project
     2. Name: Corneal protome of trangenic TGFBI R124H mouse model