PXD012896

PXD012896 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics and Real-Time PCR reveal downregulation of CXCR4 as a downstream effect of angiotensin-(1-7) treatment after experimental myocardial infarction
Description	Angiotensin-(1-7) (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system. The cardioprotective role of Ang-(1-7) has been described due to its anti-inflammatory and anti-fibrotic activities. In this context, we investigated the impact of the oral formulation of Ang-(1-7) vehiculized in hydroxypropyl β-cyclodextrin (HPβCD) on cardiac proteome remodeling after experimental myocardial infarction. For this, Wistar male rats were submitted to short- (7 days) or long-term (60 days) oral treatment with HPβCD/Ang-(1-7) after induction of experimental myocardial infarction (MI)
HostingRepository	PRIDE
AnnounceDate	2019-08-19
AnnouncementXML	Submission_2019-08-19_02:41:28.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thiago Verano-Braga
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-27 07:05:42	ID requested
⏵ 1	2019-08-19 02:41:29	announced

Dataset with its publication pending

submitter keyword: angiotensin-(1-7), heart, inflammation, mass spectrometry, myocardial infarction, proteomics

Thiago Verano Braga
contact affiliation	Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte – MG, CEP: 31270-901, Brazil.
contact email	tvbraga@icb.ufmg.br
lab head
Thiago Verano-Braga
contact affiliation	Federal University of Minas Gerais
contact email	npf.ufmg@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD012896

PRIDE project URI

• PRIDE
  1. PXD012896
     1. Label: PRIDE project
     2. Name: Quantitative proteomics and Real-Time PCR reveal downregulation of CXCR4 as a downstream effect of angiotensin-(1-7) treatment after experimental myocardial infarction