PXD012891

PXD012891 is an original dataset announced via ProteomeXchange.

Title	Proteome allocation of budding yeast under different growth rates
Description	Metabolism is at the core of cellular function as it provides free energy and building blocks required for cellular growth, and it has evolved to contain extensive regulation to adjust the activity of each pathway to the cellular needs at a given time. Here we used yeast as model to study how flux through the metabolic network is controlled. Using a systems biology approach, where we combined multi-omics analysis with metabolic modelling, we could classify overall regulatory patterns in key cellular pathways. We conclude that whereas transcriptional regulation is dominant for most metabolic pathways, there is increased enzyme saturation for increased specific growth rates, but glycolysis stands out as having far more complex regulation, which involves both protein-phosphorylation and metabolite-enzyme interactions.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:25:57.501.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jianye Xia
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-27 06:25:48	ID requested
1	2021-09-08 09:30:33	announced
⏵ 2	2024-10-22 05:26:03	announced	2024-10-22: Updated project metadata.

Yu R, Vorontsov E, Sihlbom C, Nielsen J, Quantifying absolute gene expression profiles reveals distinct regulation of central carbon metabolism genes in yeast. Elife, 10():(2021) [pubmed]

10.7554/elife.65722;

submitter keyword: LC-MSMS, Q Exactive,Saccharomyces cerevisiae

Jens Nielsen
contact affiliation	Chalmers University of Technology
contact email	nielsenj@chalmers.se
lab head
Jianye Xia
contact affiliation	East China University of Science and Technology
contact email	JIANYE.XIA2017@GMAIL.COM
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD012891

PRIDE project URI

• PRIDE
  1. PXD012891
     1. Label: PRIDE project
     2. Name: Proteome allocation of budding yeast under different growth rates