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PXD012891

PXD012891 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome allocation of budding yeast under different growth rates
DescriptionMetabolism is at the core of cellular function as it provides free energy and building blocks required for cellular growth, and it has evolved to contain extensive regulation to adjust the activity of each pathway to the cellular needs at a given time. Here we used yeast as model to study how flux through the metabolic network is controlled. Using a systems biology approach, where we combined multi-omics analysis with metabolic modelling, we could classify overall regulatory patterns in key cellular pathways. We conclude that whereas transcriptional regulation is dominant for most metabolic pathways, there is increased enzyme saturation for increased specific growth rates, but glycolysis stands out as having far more complex regulation, which involves both protein-phosphorylation and metabolite-enzyme interactions.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:25:57.501.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJianye Xia
SpeciesList scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-02-27 06:25:48ID requested
12021-09-08 09:30:33announced
22024-10-22 05:26:03announced2024-10-22: Updated project metadata.
Publication List
Yu R, Vorontsov E, Sihlbom C, Nielsen J, Quantifying absolute gene expression profiles reveals distinct regulation of central carbon metabolism genes in yeast. Elife, 10():(2021) [pubmed]
10.7554/elife.65722;
Keyword List
submitter keyword: LC-MSMS, Q Exactive,Saccharomyces cerevisiae
Contact List
Jens Nielsen
contact affiliationChalmers University of Technology
contact emailnielsenj@chalmers.se
lab head
Jianye Xia
contact affiliationEast China University of Science and Technology
contact emailJIANYE.XIA2017@GMAIL.COM
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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