PXD012891 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteome allocation of budding yeast under different growth rates |
Description | Metabolism is at the core of cellular function as it provides free energy and building blocks required for cellular growth, and it has evolved to contain extensive regulation to adjust the activity of each pathway to the cellular needs at a given time. Here we used yeast as model to study how flux through the metabolic network is controlled. Using a systems biology approach, where we combined multi-omics analysis with metabolic modelling, we could classify overall regulatory patterns in key cellular pathways. We conclude that whereas transcriptional regulation is dominant for most metabolic pathways, there is increased enzyme saturation for increased specific growth rates, but glycolysis stands out as having far more complex regulation, which involves both protein-phosphorylation and metabolite-enzyme interactions. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:25:57.501.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jianye Xia |
SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-02-27 06:25:48 | ID requested | |
1 | 2021-09-08 09:30:33 | announced | |
⏵ 2 | 2024-10-22 05:26:03 | announced | 2024-10-22: Updated project metadata. |
Publication List
Yu R, Vorontsov E, Sihlbom C, Nielsen J, Quantifying absolute gene expression profiles reveals distinct regulation of central carbon metabolism genes in yeast. Elife, 10():(2021) [pubmed] |
10.7554/elife.65722; |
Keyword List
submitter keyword: LC-MSMS, Q Exactive,Saccharomyces cerevisiae |
Contact List
Jens Nielsen |
contact affiliation | Chalmers University of Technology |
contact email | nielsenj@chalmers.se |
lab head | |
Jianye Xia |
contact affiliation | East China University of Science and Technology |
contact email | JIANYE.XIA2017@GMAIL.COM |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD012891 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD012891
- Label: PRIDE project
- Name: Proteome allocation of budding yeast under different growth rates