PXD012858 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Global proteome analysis of ATF4 targets during ER stress. |
Description | Cancer cells exploit many of the cellular adaptive responses to support their survival needs. One such critical pathway in eukaryotic cells is the unfolded protein response (UPR) that is important in normal physiology as well as disease states, including cancer. Since UPR can serve as a lever between survival and death, regulated control of its activity is critical for tumor formation and growth although the underlying mechanisms are poorly understood. Here we show that one of the main transcriptional effectors of UPR, activating transcription factor 4 (ATF4), is essential for prostate cancer (PCa) growth and survival. To identify ATF4 target genes that mediate the ISR outcome and to get insight into its mechanism of action in PCa, we performed global proteomic expression profiling in parallel with transcriptomic expression profiling. These data show that ATF4 regulates important metabolic pathways in PCa cells. |
HostingRepository | PRIDE |
AnnounceDate | 2019-07-22 |
AnnouncementXML | Submission_2019-07-22_08:40:56.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD012858 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Nora Pällmann |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | Oxidation; Acetyl; Carbamidomethyl |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-02-25 01:39:26 | ID requested | |
⏵ 1 | 2019-07-22 08:40:58 | announced | |
Publication List
P, ä, llmann N, Livg, å, rd M, Tesikova M, Zeynep Nenseth H, Akkus E, Sikkeland J, Jin Y, Koc D, Kuzu OF, Pradhan M, Danielsen HE, Kahraman N, Mokhlis HM, Ozpolat B, Banerjee PP, Uren A, Fazli L, Rennie PS, Jin Y, Saatcioglu F, Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer. Oncogene, 38(35):6301-6318(2019) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Human, LNCaP cells, LC-MS |
Contact List
Fahri Saatcioglu |
contact affiliation | Oslo University, Department of Biosciences, Section for Biochemistry and Molecular Biology, Oslo, Norway |
contact email | fahris@ibv.uio.no |
lab head | |
Nora Pällmann |
contact affiliation | University of Oslo |
contact email | nora.pallmann@ibv.uio.no |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD012858
- Label: PRIDE project
- Name: Global proteome analysis of ATF4 targets during ER stress.