PXD012858

PXD012858 is an original dataset announced via ProteomeXchange.

Title	Global proteome analysis of ATF4 targets during ER stress.
Description	Cancer cells exploit many of the cellular adaptive responses to support their survival needs. One such critical pathway in eukaryotic cells is the unfolded protein response (UPR) that is important in normal physiology as well as disease states, including cancer. Since UPR can serve as a lever between survival and death, regulated control of its activity is critical for tumor formation and growth although the underlying mechanisms are poorly understood. Here we show that one of the main transcriptional effectors of UPR, activating transcription factor 4 (ATF4), is essential for prostate cancer (PCa) growth and survival. To identify ATF4 target genes that mediate the ISR outcome and to get insight into its mechanism of action in PCa, we performed global proteomic expression profiling in parallel with transcriptomic expression profiling. These data show that ATF4 regulates important metabolic pathways in PCa cells.
HostingRepository	PRIDE
AnnounceDate	2019-07-22
AnnouncementXML	Submission_2019-07-22_08:40:56.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD012858
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Nora Pällmann
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Acetyl; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-02-25 01:39:26	ID requested
⏵ 1	2019-07-22 08:40:58	announced

P, ä, llmann N, Livg, å, rd M, Tesikova M, Zeynep Nenseth H, Akkus E, Sikkeland J, Jin Y, Koc D, Kuzu OF, Pradhan M, Danielsen HE, Kahraman N, Mokhlis HM, Ozpolat B, Banerjee PP, Uren A, Fazli L, Rennie PS, Jin Y, Saatcioglu F, Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer. Oncogene, 38(35):6301-6318(2019) [pubmed]

curator keyword: Biological

submitter keyword: Human, LNCaP cells, LC-MS

Fahri Saatcioglu
contact affiliation	Oslo University, Department of Biosciences, Section for Biochemistry and Molecular Biology, Oslo, Norway
contact email	fahris@ibv.uio.no
lab head
Nora Pällmann
contact affiliation	University of Oslo
contact email	nora.pallmann@ibv.uio.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/07/PXD012858

PRIDE project URI

• PRIDE
  1. PXD012858
     1. Label: PRIDE project
     2. Name: Global proteome analysis of ATF4 targets during ER stress.