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PXD012858

PXD012858 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGlobal proteome analysis of ATF4 targets during ER stress.
DescriptionCancer cells exploit many of the cellular adaptive responses to support their survival needs. One such critical pathway in eukaryotic cells is the unfolded protein response (UPR) that is important in normal physiology as well as disease states, including cancer. Since UPR can serve as a lever between survival and death, regulated control of its activity is critical for tumor formation and growth although the underlying mechanisms are poorly understood. Here we show that one of the main transcriptional effectors of UPR, activating transcription factor 4 (ATF4), is essential for prostate cancer (PCa) growth and survival. To identify ATF4 target genes that mediate the ISR outcome and to get insight into its mechanism of action in PCa, we performed global proteomic expression profiling in parallel with transcriptomic expression profiling. These data show that ATF4 regulates important metabolic pathways in PCa cells.
HostingRepositoryPRIDE
AnnounceDate2019-07-22
AnnouncementXMLSubmission_2019-07-22_08:40:56.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD012858
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterNora Pällmann
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListOxidation; Acetyl; Carbamidomethyl
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-02-25 01:39:26ID requested
12019-07-22 08:40:58announced
Publication List
P, ä, llmann N, Livg, å, rd M, Tesikova M, Zeynep Nenseth H, Akkus E, Sikkeland J, Jin Y, Koc D, Kuzu OF, Pradhan M, Danielsen HE, Kahraman N, Mokhlis HM, Ozpolat B, Banerjee PP, Uren A, Fazli L, Rennie PS, Jin Y, Saatcioglu F, Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer. Oncogene, 38(35):6301-6318(2019) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: Human, LNCaP cells, LC-MS
Contact List
Fahri Saatcioglu
contact affiliationOslo University, Department of Biosciences, Section for Biochemistry and Molecular Biology, Oslo, Norway
contact emailfahris@ibv.uio.no
lab head
Nora Pällmann
contact affiliationUniversity of Oslo
contact emailnora.pallmann@ibv.uio.no
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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